The understanding of the exposure to and impact of metals on human reproductive health is limited and represents a knowledge gap that has been a challenge to fill. Therefore, the goal of the Northwestern University Superfund Research Center in Reproductive Health Hazards (NU SRC) is to investigate the effects of environmental metal contaminants on reproductive function. By determining the impact of metals on gamete (egg and sperm) function and reproductive health and developing novel bioassays to assess the risk of environmental metals on reproductive function, the team can determine the longitudinal risk of environmental metals exposure to human reproductive health. The team will evaluate the routes that environmental metal contaminants take to enter human populations in coordination with the development of methods for detecting and removing select metals that pose a threat to human health.