The role of the extracellular matrix in ovarian follicle development.
Reprod Sci. 2007 Dec;14(8 Suppl):6-10
Authors: Woodruff TK, Shea LD
Regulation of ovarian follicle development depends on endocrine- and paracrine-acting hormones, the 3-dimensional architecture of the follicle, and the physical rigidity of the surrounding tissue. These 3 forces are integrated throughout the life cycle of the follicle to ensure appropriate hormone secretion, differentiation of the somatic cells, and maturation of the oocyte. The process of in-follicle maturation provides a new tool for understanding ovarian follicle development under the influence of these factors.
PMID: 18089604 [PubMed - indexed for MEDLINE]