Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle
Science. 1988 Mar 11;239(4845):1296-9
Authors: Woodruff TK, D’Agostino J, Schwartz NB, Mayo KE
Abstract:
The alterations in morphology and function of the ovarian follicle as it matures, ovulates, and becomes a corpus luteum are dramatic. A variety of steroid and polypeptide hormones influence these processes, and the ovary in turn produces specific hormonal signals for endocrine regulation. One such signal is inhibin, a heterodimeric protein that suppresses the secretion of follicle-stimulating hormone from pituitary gonadotrophs. Rat inhibin complementary DNA probes have been used to examine the levels and distribution of inhibin alpha-and beta A-subunit messenger RNAs in the ovaries of cycling animals. Striking, dynamic changes have been found in inhibin messenger RNA accumulation during the developmental maturation of the ovarian follicle.
doi: 10.1126/science.3125611. PMID: 3125611.