Learn about the conditions developed to support culture of primordial follicles from primates. Using biomaterials, we mimic the rigidity of the ovarian environment, which lays the foundation for studying the basic biology of primordial follicles in a controlled environment and for…
This work identifies the mechanism of the c-Abl kinase inhibitor imatinib mesylate, which has recently been identified as a fertoprotective agent against the alkylating chemotherapy cisplatin. We show that, in vitro, imatinib prevents cisplatin-induced apoptosis of oocytes within primordial follicles by inhibiting c-Able kinase and downstream…