Microarray analysis identifies COMP as the most differentially regulated transcript throughout in vitro follicle growth.
Mol Reprod Dev. 2012 Dec 14;
Authors: Skory RM, Bernabé BP, Galdones E, Broadbelt LJ, Shea LD, Woodruff TK
Abstract In vitro follicle growth has emerged as a technology that can provide new information about…
The maternal-to-zygotic transition: An asynchronous split.
Mol Reprod Dev. 2012 Dec 4;
Authors: Kong BY, Woodruff TK
Abstract The early cell cycles of preimplantation embryo development are unique in the scheme of mitotic cell proliferation as cell division is not coupled to cell growth, leading to a halving of blastomere…
Evidence for Chromosome 2p16.3 Polycystic Ovary Syndrome Susceptibility Locus in Affected Women of European Ancestry.
J Clin Endocrinol Metab. 2012 Nov 1;
Authors: Mutharasan P, Galdones E, Peñalver Bernabé B, Garcia OA, Jafari N, Shea LD, Woodruff TK, Legro RS, Dunaif A, Urbanek M
Abstract Context:A previous genome-wide association study…
Multiple follicle culture supports primary follicle growth through paracrine-acting signals.
Reproduction. 2012 Oct 29;
Authors: Hornick J, Duncan FE, Shea L, Woodruff TK
Abstract In vitro follicle growth in alginate hydrogels is a unique and versatile method for studying ovarian and follicle biology that may also have implications for fertility…
Repropedia: A Reproductive Lexicon to Fill the Gap in Reproductive Terminology.
Biol Reprod. 2012 Sep 26;
Authors: Smeyers C, Wallach H, Woodruff TK
Abstract The general public and students have incomplete comprehension of reproductive science terminology. This lack of knowledge creates barriers to discussions about reproductive biology and health and…
Chromosome cohesion decreases in human eggs with advanced maternal age.
Aging Cell. 2012 Jul 23;
Authors: Duncan FE, Hornick JE, Lampson MA, Schultz RM, Shea LD, Woodruff TK
Abstract Aneuploidy in human eggs increases with maternal age and can result in infertility, miscarriages, and birth defects. The molecular mechanisms leading…
Bipolar-to-monopolar spindle collapse in human eggs.
Mol Reprod Dev. 2012 Jul 9;
Authors: Duncan FE, Hornick JE, Woodruff TK
Abstract The bipolar spindle is an integral part of the cell division machinery required for faithful chromosome segregation. During meiosis in the mammalian females, this machinery must function sequentially during a…
Quantification of anti-Mullerian hormone (AMH) in dried blood spots: validation of a minimally invasive method for assessing ovarian reserve.
Hum Reprod. 2012 Jun 6;
Authors: McDade TW, Woodruff TK, Huang YY, Funk WE, Prewitt M, Kondapalli L, Gracia CR
Abstract BACKGROUNDBiological markers of ovarian reserve have the potential to advance…
Isolated primate primordial follicles require a rigid physical environment to survive and grow in vitro.
Hum Reprod. 2012 Jun;27(6):1801-10
Authors: Hornick JE, Duncan FE, Shea LD, Woodruff TK
Abstract BACKGROUND: In vitro follicle growth is a promising fertility preservation strategy in which ovarian follicles are cultured to produce mature and…
Embryonic fibroblasts enable the culture of primary ovarian follicles within alginate hydrogels.
Tissue Eng Part A. 2012 Jun;18(11-12):1229-38
Authors: Tagler D, Tu T, Smith RM, Anderson NR, Tingen CM, Woodruff TK, Shea LD
Abstract Hydrogel-encapsulating culture systems support the consistent growth of ovarian follicles from various species, such as mouse,…
Age-associated alteration of oocyte-specific gene expression in polar bodies: potential markers of oocyte competence.
Fertil Steril. 2012 May 24;
Authors: Jiao ZX, Xu M, Woodruff TK
Abstract OBJECTIVE: To confirm that oocyte-specific messenger RNAs are detectable in the polar body (PB) of metaphase II (MII) oocytes and determine the effect of age…
A zinc-dependent mechanism regulates meiotic progression in mammalian oocytes.
Biol Reprod. 2012 Apr;86(4):114
Authors: Bernhardt ML, Kong BY, Kim AM, O'Halloran TV, Woodruff TK
Abstract Precise coordination of meiotic progression is a critical determinant of an egg's capacity to be fertilized successfully, and zinc has emerged as a key regulatory…
Inhibin α-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.
J Biol Chem. 2012 Mar 9;287(11):8060-70
Authors: Zhu J, Lin SJ, Zou C, Makanji Y, Jardetzky TS, Woodruff TK
Abstract Inhibin is a heterodimeric peptide hormone produced in the ovary that antagonizes activin signaling and FSH…
Improved fertility preservation care for male patients with cancer after establishment of formalized oncofertility program.
J Urol. 2012 Mar;187(3):979-86
Authors: Sheth KR, Sharma V, Helfand BT, Cashy J, Smith K, Hedges JC, Köhler TS, Woodruff TK, Brannigan RE
Abstract PURPOSE: Survival to reproductive age among men with cancer has steadily…
The possible role of resource requirements and academic career-choice risk on gender differences in publication rate and impact.
PLoS One. 2012;7(12):e51332
Authors: Duch J, Zeng XH, Sales-Pardo M, Radicchi F, Otis S, Woodruff TK, Nunes Amaral LA
Abstract
Many studies demonstrate that there is still a significant gender bias, especially at higher career levels, in many areas including science,…
Zinc Maintains Prophase I Arrest in Mouse Oocytes Through Regulation of the MOS-MAPK Pathway.
Biol Reprod. 2012;87(1):11
Authors: Kong BY, Bernhardt ML, Kim AM, O'Halloran TV, Woodruff TK
Abstract Meiosis in mammalian females is marked by two arrest points, at prophase I and metaphase II, which must be tightly regulated…