An emerging role for co-receptors in inhibin signal transduction.
Mol Cell Endocrinol. 2001 Jun 30;180(1-2):55-62
Authors: Bernard DJ, Chapman SC, Woodruff TK
While many transforming growth factor-beta (TGFbeta) superfamily ligands such as TGFbeta, activin, and the bone morphogenic proteins (BMPs) are critical to the control of growth, differentiation, and cell fate, inhibin has a more limited role and…
Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).
Mol Endocrinol. 2001 Apr;15(4):668-79
Authors: Chapman SC, Woodruff TK
An antagonistic relationship between inhibin and activin is essential to the control of pituitary FSH release and to normal gonadal function. Two inhibin ligands, inhibin A and inhibin B, are made by the ovary in females, and…
Inhibin binding protein in rats: alternative transcripts and regulation in the pituitary across the estrous cycle.
Mol Endocrinol. 2001 Apr;15(4):654-67
Authors: Bernard DJ, Woodruff TK
Inhibin binding protein (InhBP) and the transforming growth factor-beta (TGF beta) type III receptor, beta glycan, have been identified as putative inhibin coreceptors. Here we cloned the InhBP cDNA in rats and predict…
Mechanisms of inhibin signal transduction.
Recent Prog Horm Res. 2001;56:417-50
Authors: Bernard DJ, Chapman SC, Woodruff TK
Inhibin was first identified as a gonadal hormone that potently inhibits pituitary follicle-stimulating hormone (FSH) synthesis and secretion. Although the notion of a nonsteroidal, gonadally derived inhibitory substance was realized in the early 1930s (McCullagh, 1932), identification of the hormone was…