Follicle isolation methods reveal plasticity of granulosa cell steroidogenic capacity during mouse in vitro follicle growth
Mol Hum Reprod. 2022 Sep 29;28(10):gaac033
Authors: Babayev E, Xu M, Shea LD, Woodruff TK, Duncan FE
Abstract:
Follicles are the functional unit of the ovary and several methods have been developed to grow follicles ex vivo, which recapitulate key events of oogenesis and…
Broadening the educational pipeline: the global landscape of master of science programs in reproductive science and medicine
Biol Reprod. 2022 Sep 12;107(3):664-675
Authors: Ataman-Millhouse LM, Monahan P, Willingham R, Vigone G, Soulakis M, Gadea J, Jiménez-Movilla M, Romar R, Cánovas S, Woodruff TK, Duncan FE
Abstract:
Reproductive health underpins overall health, and thus, research in reproductive science and medicine is…
Gender-diverse teams produce more novel and higher-impact scientific ideas
Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2200841119
Authors: Yang Y, Tian TY, Woodruff TK, Jones BF, Uzzi B
Abstract:
Science's changing demographics raise new questions about research team diversity and research outcomes. We study mixed-gender research teams, examining 6.6 million papers published across the medical sciences since 2000…
Dynamic zinc fluxes regulate meiotic progression in Caenorhabditis elegans†
Biol Reprod. 2022 Aug 9;107(2):406-418
Author: Mendoza AD, Sue A, Antipova O, Vogt S, Woodruff TK, Wignall SM, O'Halloran TV
Abstract:
Zinc influx and efflux events are essential for meiotic progression in oocytes of several mammalian and amphibian species, but it is less clear whether this evolutionary conservation of zinc signals…
A synopsis of global frontiers in fertility preservation
J Assist Reprod Genet. 2022 Aug;39(8):1693-1712
Authors: Ataman LM, Laronda MM, Gowett M, Trotter K, Anvari H, Fei F, Ingram A, Minette M, Suebthawinkul C, Taghvaei Z, Torres-Vélez M, Velez K, Adiga SK, Anazodo A, Appiah L, Bourlon MT, Daniels N, Dolmans MM, Finlayson C, Gilchrist RB, Gomez-Lobo V, Greenblatt…
An Ovarian Steroid Metabolomic Pathway Analysis in Basal and Polycystic Ovary Syndrome (PCOS)-like Gonadotropin Conditions Reveals a Hyperandrogenic Phenotype Measured by Mass Spectrometry
Biomedicines. 2022 Jul 8;10(7):1646
Authors: Gargus ES, Bae Y, Chen J, Moss KJ, Ingram AN, Zhang J, Montgomery NT, Boots CE, Funk WE, Woodruff TK
Abstract:
Prior work has demonstrated that murine ovarian explants and isolated ovarian…
Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation
Reproduction. 2022 Jul 7;164(2):55-70
Authors: Chen YY, Russo DD, Drake RS, Duncan FE, Shalek AK, Goods BA, Woodruff TK
Abstract:
In brief: Proper development of ovarian follicles, comprised of an oocyte and surrounding somatic cells, is essential to support female fertility and endocrine health. Here, we describe…
Zinc transporters ZIPT-2.4 and ZIPT-15 are required for normal C. elegans fecundity
J Assist Reprod Genet. 2022 Jun;39(6):1261-1276
Authors: Sue AC, Wignall SM, Woodruff TK, O'Halloran TV
Abstract:
Purpose: The requirement of zinc for the development and maturation of germ lines and reproductive systems is deeply conserved across evolution. The nematode Caenorhabditis elegans offers a tractable platform to study the complex…
Installing oncofertility programs for breast cancer in limited versus optimum resource settings: Empirical data from 39 surveyed centers in Repro-Can-OPEN Study Part I & II
J Assist Reprod Genet. 2022 Feb;39(2):505-516
Authors: Salama M, Lambertini M, Christianson MS, Jayasinghe Y, Anazodo A, De Vos M, Amant F, Stern C, Appiah L, Woodard TL, Anderson RA, Westphal LM, Leach…