Activin regulates estrogen receptor gene expression in the mouse ovary.
J Biol Chem. 2007 Dec 14;282(50):36755-65
Authors: Kipp JL, Kilen SM, Woodruff TK, Mayo KE
Abstract Activin, a member of the transforming growth factor-beta superfamily, is an important modulator of follicle-stimulating hormone synthesis and secretion in the pituitary and plays…
The role of the extracellular matrix in ovarian follicle development.
Reprod Sci. 2007 Dec;14(8 Suppl):6-10
Authors: Woodruff TK, Shea LD
Abstract Regulation of ovarian follicle development depends on endocrine- and paracrine-acting hormones, the 3-dimensional architecture of the follicle, and the physical rigidity of the surrounding tissue. These 3 forces are…
Physical properties of alginate hydrogels and their effects on in vitro follicle development.
Biomaterials. 2007 Oct;28(30):4439-48
Authors: West ER, Xu M, Woodruff TK, Shea LD
Abstract The mechanical properties and density of natural and synthetic extracellular matrices are known to affect cellular processes and regulate tissue formation. In this report,…
Activin and estrogen crosstalk regulates transcription in human breast cancer cells.
Endocr Relat Cancer. 2007 Sep;14(3):679-89
Authors: Burdette JE, Woodruff TK
Abstract Activin is a member of the transforming growth factor beta superfamily that regulates mammary cell function during development, lactation, and in cancer. Activin slows the growth of breast…
Ovarian epithelial inclusion cysts in chronically superovulated CD1 and Smad2 dominant-negative mice.
Endocrinology. 2007 Aug;148(8):3595-604
Authors: Burdette JE, Oliver RM, Ulyanov V, Kilen SM, Mayo KE, Woodruff TK
Abstract Chronic ovulation as a contributing factor for the development of epithelial ovarian cancer in women has long been an outstanding hypothesis.…
Eggs in the nest.
Endocrinology. 2007 Aug;148(8):3577-9
Authors: Mayo K, Jameson L, Woodruff TK
PMID: 17639032 [PubMed - indexed for MEDLINE]
Rational design, synthesis, and biological evaluation of progesterone-modified MRI contrast agents.
Chem Biol. 2007 Jul;14(7):824-34
Authors: Lee J, Burdette JE, MacRenaris KW, Mustafi D, Woodruff TK, Meade TJ
Abstract A series of contrast agents for magnetic resonance imaging (MRI) aimed at noninvasively determining the hormone receptor status of cancer in…
N-linked oligosaccharides direct the differential assembly and secretion of inhibin alpha- and betaA-subunit dimers.
Mol Endocrinol. 2007 Jul;21(7):1670-84
Authors: Antenos M, Stemler M, Boime I, Woodruff TK
Abstract The biosynthetic pathway governing inhibin heterodimer (alpha/beta) and activin homodimer (beta/beta) assembly and secretion from ovarian granulosa cells is not fully understood.…
Engineering the follicle microenvironment.
Semin Reprod Med. 2007 Jul;25(4):287-99
Authors: West ER, Shea LD, Woodruff TK
Abstract In vitro ovarian follicle culture provides a tool to investigate folliculogenesis, and may one day provide women with fertility-preservation options. The application of tissue engineering principles to ovarian follicle maturation may enable the…
Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions.
Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions.
J Biol Chem. 2007 May 25;282(21):15930-9
Authors: Lerch TF, Shimasaki S, Woodruff TK, Jardetzky TS
Abstract Follistatin (FS) regulates transforming growth factor-beta superfamily ligands and is necessary for normal embryonic and ovarian follicle development. Follistatin is expressed…
Neonatal exposure to estrogens suppresses activin expression and signaling in the mouse ovary.
Endocrinology. 2007 May;148(5):1968-76
Authors: Kipp JL, Kilen SM, Bristol-Gould S, Woodruff TK, Mayo KE
Abstract In the ovary, the steroid hormone estrogen and the TGF-beta superfamily member activin are both produced by granulosa cells and they both…
The structures that underlie normal reproductive function.
Mol Cell Endocrinol. 2007 Mar 15;267(1-2):1-5
Authors: Lerch TF, Xu M, Jardetzky TS, Mayo KE, Radhakrishnan I, Kazer R, Shea LD, Woodruff TK
Abstract The mechanisms and physiology of reproductive function have fascinated scientists throughout time. Recent cellular and molecular level structural studies…
Bioengineering and the ovarian follicle.
Cancer Treat Res. 2007;138:75-82
Authors: Xu M, Woodruff TK, Shea LD
PMID: 18080658 [PubMed - indexed for MEDLINE]
Oncofertility consortium consensus statement: guidelines for ovarian tissue cryopreservation.
Cancer Treat Res. 2007;138:235-9
Authors: Backhus LE, Kondapalli LA, Chang RJ, Coutifaris C, Kazer R, Woodruff TK
PMID: 18080669 [PubMed - indexed for MEDLINE]
The emergence of a new interdiscipline: oncofertility.
Cancer Treat Res. 2007;138:3-11
Authors: Woodruff TK
PMID: 18080653 [PubMed - indexed for MEDLINE]
Fertility preservation and adolescent cancer patients: lessons from adult survivors of childhood cancer and their parents.
Cancer Treat Res. 2007;138:201-17
Authors: Nieman CL, Kinahan KE, Yount SE, Rosenbloom SK, Yost KJ, Hahn EA, Volpe T, Dilley KJ, Zoloth L, Woodruff TK
PMID: 18080667 [PubMed - indexed for MEDLINE]