Ovarian follicular concentrations of activin, follistatin, inhibin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-2 (IGFBP-2), IGFBP-3, and vascular endothelial growth factor in spontaneous menstrual cycles of normal women of advanced reproductive age.
J Clin Endocrinol Metab. 2000 Dec;85(12):4520-5
Authors: Klein NA, Battaglia DE, Woodruff TK, Padmanabhan V, Giudice LC, Bremner WJ, Soules MR
Previous studies indicate that…
Activin signal transduction pathways.
Trends Endocrinol Metab. 2000 Oct;11(8):309-14
Authors: Pangas SA, Woodruff TK
Many of the signal transduction pathways required for mammalian endocrine cell function are conserved from flies and worms. These model organisms permitted the illumination of the biological properties of ligands and provided systems in which cellular coactivating molecules could be identified rapidly. Our knowledge…
Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions.
Nat Genet. 2000 Aug;25(4):453-7
Authors: Brown CW, Houston-Hawkins DE, Woodruff TK, Matzuk MM
The activins (dimers of betaA or betaB subunits, encoded by the genes Inhba and Inhbb, respectively) are TGF-beta superfamily members that have roles in reproduction and development. Whereas mice…
Structure and expression of a membrane component of the inhibin receptor system.
Endocrinology. 2000 Jul;141(7):2600-7
Authors: Chong H, Pangas SA, Bernard DJ, Wang E, Gitch J, Chen W, Draper LB, Cox ET, Woodruff TK
The purification and cloning of a membrane-anchored proteoglycan with affinity for inhibin A are described. Bovine pituitary membranes were isolated, and membrane-anchored proteins were…
Activin A-induced HepG2 liver cell apoptosis: involvement of activin receptors and smad proteins.
Endocrinology. 2000 Mar;141(3):1263-72
Authors: Chen W, Woodruff TK, Mayo KE
A balance between cell proliferation and apoptosis is important for regulating normal liver function. Proteins of the transforming growth factor-beta superfamily are known to be important mediators of apoptosis in the liver. In this study…