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Activin stimulates spermatogonial proliferation in germ-Sertoli cell cocultures from immature rat testis

Activin stimulates spermatogonial proliferation in germ-Sertoli cell cocultures from immature rat testis Endocrinology. 1990 Dec;127(6):3206-14 Authors: Mather JP, Attie KM, Woodruff TK, Rice GC, Phillips DM Abstract: Activin and inhibin are peptide hormones produced in the gonads which may act as autocrine and/or paracrine regulators of testicular function. Sertoli cells produce inhibin, and it has recently been shown that Leydig…

Inhibin and activin locally regulate rat ovarian folliculogenesis

Inhibin and activin locally regulate rat ovarian folliculogenesis Endocrinology. 1990 Dec;127(6):3196-205 Authors: Woodruff TK, Lyon RJ, Hansen SE, Rice GC, Mather JP Abstract: The role of inhibin and activin in the initiation of follicular development, growth, and atresia was examined. Human recombinant inhibin (1 microgram) was unilaterally injected into the ovarian intrabursal space of 25-day-old rats. The contralateral ovary served…

Regulation of inhibin synthesis in the rat ovary

Regulation of inhibin synthesis in the rat ovary Annu Rev Physiol. 1990;52:807-21 Authors: Woodruff TK, Mayo KE Abstract: The lifespan of the female rodent is characterized by dynamic changes in the hormonal regulation of the reproductive axis. From the time ovarian follicular growth is initiated in peripubertal animals, through recruitment, ovulation and luteinization during the estrous cycle, to the quiescent…