Creating a continuum of care: integrating obstetricians and gynecologists in the care of young cancer patients.
Clin Obstet Gynecol. 2011 Dec;54(4):619-32
Authors: Kong BY, Skory RM, Woodruff TK
Abstract Cancer therapy can be lifesaving but significantly diminish female reproductive potential. This review provides an overview of the deleterious effects…
Understanding Technology and Human Interaction to Catalyze Oncofertility and Adolescent and Young Adult Oncology Research.
J Adolesc Young Adult Oncol. 2011 Dec;1(4):160-163
Authors: Waimey KE, Krausfeldt AD, Taylor RL, Wallach HD, Woodruff TK
PMID: 23610736 [PubMed - as supplied by publisher]
Fibrin encapsulation and vascular endothelial growth factor delivery promotes ovarian graft survival in mice.
Tissue Eng Part A. 2011 Dec;17(23-24):3095-104
Authors: Shikanov A, Zhang Z, Xu M, Smith RM, Rajan A, Woodruff TK, Shea LD
Abstract Ovarian cryopreservation before chemotherapy and autotransplantation post-treatment can restore fertility to women with premature…
Nonmalignant diseases and treatments associated with primary ovarian failure: an expanded role for fertility preservation.
J Womens Health (Larchmt). 2011 Oct;20(10):1467-77
Authors: Hirshfeld-Cytron J, Gracia C, Woodruff TK
Abstract Cancer treatments can be detrimental to fertility; recent literature has focused on the efforts of fertility preservation for this patient population.…
Altered gonadal expression of TGF-β superfamily signaling factors in environmental contaminant-exposed juvenile alligators.
J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):58-63
Authors: Moore BC, Milnes MR, Kohno S, Katsu Y, Iguchi T, Woodruff TK, Guillette LJ
Abstract Environmental contaminant exposure can influence gonadal steroid signaling milieus; however, little research has investigated…
Animal age, weight and estrus cycle stage impact the quality of in vitro grown follicles.
Hum Reprod. 2011 Sep;26(9):2473-85
Authors: Hirshfeld-Cytron JE, Duncan FE, Xu M, Jozefik JK, Shea LD, Woodruff TK
Abstract BACKGROUND: Ovarian tissue cryopreservation is an emerging fertility preservation option, and culturing follicles isolated from this tissue…
A truncated, activin-induced Smad3 isoform acts as a transcriptional repressor of FSHβ expression in mouse pituitary.
Mol Cell Endocrinol. 2011 Aug 6;342(1-2):64-72
Authors: Kim SY, Zhu J, Woodruff TK
Abstract The receptor-regulated protein Smad3 is key player in the signaling cascade stimulated by the binding of activin to its cell…
Gene expression in mouse ovarian follicle development in vivo versus an ex vivo alginate culture system.
Reproduction. 2011 Aug;142(2):309-18
Authors: Parrish EM, Siletz A, Xu M, Woodruff TK, Shea LD
Abstract Ovarian follicle maturation results from a complex interplay of endocrine, paracrine, and direct cell-cell interactions. This study compared the…
Zinc sparks are triggered by fertilization and facilitate cell cycle resumption in mammalian eggs.
ACS Chem Biol. 2011 Jul 15;6(7):716-23
Authors: Kim AM, Bernhardt ML, Kong BY, Ahn RW, Vogt S, Woodruff TK, O'Halloran TV
Abstract In last few hours of maturation, the mouse oocyte takes up over twenty billion…
In vitro growth and steroidogenesis of dog follicles are influenced by the physical and hormonal microenvironment.
Reproduction. 2011 Jul;142(1):113-22
Authors: Songsasen N, Woodruff TK, Wildt DE
Abstract The present study examined the influences of the physical and hormonal microenvironment on in vitro growth and steroidogenesis of dog follicles. Follicles were…
A macrophage and theca cell-enriched stromal cell population influences growth and survival of immature murine follicles in vitro.
Reproduction. 2011 Jun;141(6):809-20
Authors: Tingen CM, Kiesewetter SE, Jozefik J, Thomas C, Tagler D, Shea L, Woodruff TK
Abstract Innovations in in vitro ovarian follicle culture have revolutionized the field of fertility…
The time is now for a new approach to primary ovarian insufficiency.
Fertil Steril. 2011 May;95(6):1890-7
Authors: Cooper AR, Baker VL, Sterling EW, Ryan ME, Woodruff TK, Nelson LM
Abstract OBJECTIVE: To articulate the need for a new approach to primary ovarian insufficiency. The condition, also known as premature menopause…
In vitro oocyte maturation and preantral follicle culture from the luteal-phase baboon ovary produce mature oocytes.
Biol Reprod. 2011 Apr;84(4):689-97
Authors: Xu M, Fazleabas AT, Shikanov A, Jackson E, Barrett SL, Hirshfeld-Cytron J, Kiesewetter SE, Shea LD, Woodruff TK
Abstract Female cancer patients who seek fertility preservation but cannot undergo…
Hydrogel network design using multifunctional macromers to coordinate tissue maturation in ovarian follicle culture.
Biomaterials. 2011 Apr;32(10):2524-31
Authors: Shikanov A, Smith RM, Xu M, Woodruff TK, Shea LD
Abstract Synthetic hydrogels with tunable properties are appealing for regenerative medicine. A critical limitation in hydrogel design at low solids concentration is…
Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-beta binding.
Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5232-6
Authors: Lin SJ, Hu Y, Zhu J, Woodruff TK, Jardetzky TS
Abstract The zona pellucida (ZP) domain is a bipartite protein structural element comprised…
Results from the survey for preservation of adolescent reproduction (SPARE) study: gender disparity in delivery of fertility preservation message to adolescents with cancer.
J Assist Reprod Genet. 2011 Mar;28(3):269-77
Authors: Köhler TS, Kondapalli LA, Shah A, Chan S, Woodruff TK, Brannigan RE
Abstract PURPOSE: Diminished reproductive capacity is a devastating…
Zinc requirement during meiosis I-meiosis II transition in mouse oocytes is independent of the MOS-MAPK pathway.
Biol Reprod. 2011 Mar;84(3):526-36
Authors: Bernhardt ML, Kim AM, O'Halloran TV, Woodruff TK
Abstract Zinc is essential for many biological processes, including proper functioning of gametes. We recently reported that zinc levels rise by…
A method for ovarian follicle encapsulation and culture in a proteolytically degradable 3 dimensional system.
J Vis Exp. 2011;(49)
Authors: Shikanov A, Xu M, Woodruff TK, Shea LD
Abstract The ovarian follicle is the functional unit of the ovary that secretes sex hormones and supports oocyte maturation. In vitro follicle…
A new hypothesis regarding ovarian follicle development: ovarian rigidity as a regulator of selection and health.
J Assist Reprod Genet. 2011 Jan;28(1):3-6
Authors: Woodruff TK, Shea LD
Abstract The mammalian ovary consists of a large number of dormant immature follicles, each containing a single oocyte and located on the periphery…
Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin α- and β-subunits as candidate substrates.
PLoS One. 2011;6(3):e17348
Authors: Antenos M, Lei L, Xu M, Malipatil A, Kiesewetter S, Woodruff TK
Abstract Inhibin and activin are essential dimeric glycoproteins belonging to the transforming growth factor-beta (TGFβ)…
Incorporating fertility preservation into the care of young oncology patients.
Cancer. 2011 Jan 1;117(1):4-10
Authors: Redig AJ, Brannigan R, Stryker SJ, Woodruff TK, Jeruss JS
Abstract As the number of cancer survivors continues to increase, oncologists are faced with the challenge of providing cancer therapy to patients who may 1…
The Gynecologist Has a Unique Role in Providing Oncofertility Care to Young Cancer Patients.
US Obstet Gynecol. 2011 Jan 1;6(1):24-34
Authors: Duncan FE, Jozefik JK, Kim AM, Hirshfeld-Cytron J, Woodruff TK
Abstract Facing a cancer diagnosis at any age is devastating. However, young cancer patients have the added burden that…