Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan.
Cell Rep. 2017 Nov 07;21(6):1471-1480
Authors: Rai R, Ghosh AK, Eren M, Mackie AR, Levine DC, Kim SY, Cedernaes J, Ramirez V, Procissi D, Smith LH, Woodruff TK, Bass J, Vaughan DE
Abstract
Aging drives the…
Fertility Lost-Fertility Found: Narratives from the Leading Edge of Oncofertility.
Narrat Inq Bioeth. 2017;7(2):147-150
Authors: Woodruff TK
Abstract
A cancer diagnosis at a young age creates one of the most existential crises one can imagine. The good news is that for many of these young patients, they will survive their diagnosis.…
"Tissue Papers" from Organ-Specific Decellularized Extracellular Matrices.
Adv Funct Mater. 2017 Sep 13;27(3):
Authors: Jakus AE, Laronda MM, Rashedi AS, Robinson CM, Lee C, Jordan SW, Orwig KE, Woodruff TK, Shah RN
Abstract
Using an innovative, tissue-independent approach to decellularized tissue processing and biomaterial fabrication, the development of a series of…
Nonhuman Primates: A Vital Model for Basic and Applied Research on Female Reproduction, Prenatal Development, and Women's Health.
ILAR J. 2017 Aug 28;:1-14
Authors: Stouffer RL, Woodruff TK
Abstract
The comparative biology of reproduction and development in mammalian species is remarkable. Hence, because of similarities in environmental and neuroendocrine control of…
"When You're a Baby You Don't Have Puberty": Understanding of Puberty and Human Reproduction in Late Childhood and Early Adolescence.
J Early Adolesc. 2017 Aug;37(7):925-947
Authors: Hurwitz LB, Lauricella AR, Hightower B, Sroka I, Woodruff TK, Wartella E
Abstract
Basic knowledge of human reproduction can help youth prepare for puberty and…
New hope for symptom management during natural and iatrogenic menopause transitions.
Biol Reprod. 2017 Aug 01;97(2):177-178
Authors: Woodruff TK, Khosla S
Abstract
Bone loss is associated with aging and is exacerbated by female transition to menopause. Estrogen has long been associated with bone loss, and replacement therapy is effective at restoring…
Fertility preservation training for obstetrics and gynecology fellows: a highly desired but non-standardized experience.
Fertil Res Pract. 2017;3:9
Authors: Miller EJN, Cookingham LM, Woodruff TK, Ryan GL, Summers KM, Kondapalli LA, Shah DK
Abstract
BACKGROUND: Despite a large body of data suggesting that delivery of fertility care to cancer patients is…
The promise of organ and tissue preservation to transform medicine.
Nat Biotechnol. 2017 Jun 07;35(6):530-542
Authors: Giwa S, Lewis JK, Alvarez L, Langer R, Roth AE, Church GM, Markmann JF, Sachs DH, Chandraker A, Wertheim JA, Rothblatt M, Boyden ES, Eidbo E, Lee WPA, Pomahac B, Brandacher G, Weinstock DM, Elliott G, Nelson D, Acker JP, Uygun…
Global oncofertility index - data gap slows progress.
Biol Reprod. 2017 May 30;:
Authors: de Roo SF, Rashedi AS, Beerendonk CCM, Anazodo A, de Man AM, Nelen WLDM, Woodruff TK
Abstract
The number of pediatric and young adult cancer survivors is increasing globally due to earlier diagnostics and expansion of targeted…
Anticancer Treatments and Female Fertility: Clinical Concerns and Role of Oncologists in Oncofertility Practice.
Expert Rev Anticancer Ther. 2017 May 24;:
Authors: Salama M, Woodruff TK
Abstract
INTRODUCTION: Anticancer treatments such as aggressive chemotherapy and radiotherapy have deleterious gonadotoxic side effects and are considered the most common causes of pathological and…
A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice.
Nat Commun. 2017 May 16;8:15261
Authors: Laronda MM, Rutz AL, Xiao S, Whelan KA, Duncan FE, Roth EW, Woodruff TK, Shah RN
Abstract
Emerging additive manufacturing techniques enable investigation of the effects of pore geometry on…
Practices and Attitudes Regarding Women Undergoing Fertility Preservation: A Survey of the National Physicians Cooperative.
J Adolesc Young Adult Oncol. 2017 May 01;:
Authors: Bortoletto P, Confino R, Smith BM, Woodruff TK, Pavone ME
Abstract
PURPOSE: To describe physician attitudes and variations in oncofertility treatment strategies.
…
A Call for Fertility Preservation Coverage for Breast Cancer Patients: The Cost of Consistency.
J Natl Cancer Inst. 2017 May 01;109(5):
Authors: Walter JR, Xu S, Woodruff TK
Abstract
In 1998, the passage of the Women's Health and Cancer Rights Act required insurance health plans nationwide covering breast cancer treatments to…
Development of a Novel Human Recellularized Endometrium that responds to a 28 day Hormone Treatment.
Development of a Novel Human Recellularized Endometrium that responds to a 28 day Hormone Treatment.
Biol Reprod. 2017 Apr 25;:
Authors: Olalekan SA, Burdette JE, Getsios S, Woodruff TK, Kim JJ
Abstract
Three dimensional (3D) in vitro models have been established to study the physiology and pathophysiology of the endometrium. With…
A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle.
Nat Commun. 2017 Mar 28;8:14584
Authors: Xiao S, Coppeta JR, Rogers HB, Isenberg BC, Zhu J, Olalekan SA, McKinnon KE, Dokic D, Rashedi AS, Haisenleder DJ, Malpani SS, Arnold-Murray CA, Chen K, Jiang M, Bai L, Nguyen CT, Zhang J, Laronda MM, Hope TJ,…
Doxorubicin has dose-dependent toxicity on mouse ovarian follicle development, hormone secretion, and oocyte maturation.
Toxicol Sci. 2017 Mar 17;:
Authors: Xiao S, Zhang J, Liu M, Iwahata H, Rogers HB, Woodruff TK
Abstract
Doxorubicin (DOX), one of the most commonly used anticancer medications, has been reported to affect fertility by damaging…
The steroid metabolome in the isolated ovarian follicle and its response to androgen exposure and antagonism.
Endocrinology. 2017 Feb 23;:
Authors: Lebbe M, Taylor AE, Visser JA, Kirkman-Brown J, Woodruff TK, Arlt W
Abstract
The ovarian follicle is a major site of steroidogenesis, crucially required for normal ovarian function and female…
A win-win for women's reproductive health: A nonsteroidal contraceptive and fertoprotective neoadjuvant.
Proc Natl Acad Sci U S A. 2017 Feb 17;:
Authors: Woodruff TK
PMID: 28213496 [PubMed - as supplied by publisher]
Fertility Preservation for Pediatric Patients: Current State and Future Possibilities.
J Urol. 2017 Feb 09;:
Authors: Johnson EK, Finlayson C, Rowell EE, Gosiengfiao Y, Pavone ME, Lockart B, Orwig KE, Brannigan RE, Woodruff TK
Abstract
PURPOSE: This review provides an overview of pediatric fertility preservation (FP). Topics covered include: patient populations…
Ethical, moral and other aspects related to fertility preservation in cancer patients.
JBRA Assist Reprod. 2017 Feb 01;21(1):45-48
Authors: Carvalho BR, Kliemchen J, Woodruff TK
Abstract
Post-treatment fertility emerges as an important issue in the early counseling of individuals with cancer, since survivors may have their quality of life affected by…
Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy.
Integr Biol (Camb). 2017 Jan 19;:
Authors: Que EL, Duncan FE, Bayer AR, Philips SJ, Roth EW, Bleher R, Gleber SC, Vogt S, Woodruff TK, O'Halloran TV
Abstract
During fertilization or chemically-induced egg activation, the mouse egg releases…