Smad4 overexpression causes germ cell ablation and leydig cell hyperplasia in transgenic mice.
Am J Pathol. 2002 Nov;161(5):1723-34
Authors: Narula A, Kilen S, Ma E, Kroeger J, Goldberg E, Woodruff TK
Members of the transforming growth factor-beta (TGF-beta) superfamily play a variety of important roles in testicular development and function. The tumor suppressor gene, Smad4, is a common…
Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors.
Mol Cell Endocrinol. 2002 Oct 31;196(1-2):79-93
Authors: Chapman SC, Bernard DJ, Jelen J, Woodruff TK
Activin-stimulated FSH synthesis and release by the pituitary gonadotrope is antagonized by gonadally derived inhibins. The two isoforms of inhibin, inhibin A and B, bind to the activin type II…
Photoperiod-dependent regulation of inhibin in Siberian hamsters: I. Ovarian inhibin production and secretion.
J Endocrinol. 2002 Jul;174(1):71-83
Authors: Kenny HA, Bernard DJ, Horton TH, Woodruff TK
Follicle-stimulating hormone (FSH) stimulates ovarian follicle development and the production of protein hormones including inhibin A and inhibin B. The inhibins are dimeric proteins (alpha-beta(A) or alpha-beta(B)) secreted by growing follicles that…
Photoperiod-dependent regulation of inhibin in Siberian hamsters: II. Regulation of inhibin production and secretion by pregnant mare serum gonadotropin.
J Endocrinol. 2002 Jul;174(1):85-94
Authors: Kenny HA, Bernard DJ, Horton TH, Woodruff TK
Inhibin production differs in ovaries of Siberian hamsters (Phodopus sungorus) exposed to long days (LD) or short days (SD). We believe that seasonal differences in serum…
Localization of the activin signal transduction components in normal human ovarian follicles: implications for autocrine and paracrine signaling in the ovary.
J Clin Endocrinol Metab. 2002 Jun;87(6):2644-57
Authors: Pangas SA, Rademaker AW, Fishman DA, Woodruff TK
The intraovarian function of gonadally produced activin is unclear, and many in vitro studies have suggested a role for activin in follicle…
Follistatin-free activin A is not associated with preterm birth.
Am J Obstet Gynecol. 2002 Mar;186(3):464-9
Authors: Wang EY, Woodruff TK, Moawad A,
OBJECTIVE: The purpose of this study was to determine whether follistatin-free activin A (an inhibin-related protein with rising serum levels before term labor) is associated with spontaneous preterm birth in an outpatient population. STUDY…
Inhibin binding protein (InhBP/p120), betaglycan, and the continuing search for the inhibin receptor.
Mol Endocrinol. 2002 Feb;16(2):207-12
Authors: Bernard DJ, Chapman SC, Woodruff TK
Betaglycan (the TGFbeta type III receptor) and InhBP/p120 (a membrane-tethered proteoglycan) were recently identified as putative inhibin receptors. Here, we review the current state of knowledge regarding these two proteins with respect to their…
Production and purification of recombinant human inhibin and activin.
J Endocrinol. 2002 Jan;172(1):199-210
Authors: Pangas SA, Woodruff TK
Inhibin and activin are protein hormones with diverse physiological roles including the regulation of pituitary FSH secretion. Like other members of the transforming growth factor-beta gene family, they undergo processing from larger precursor molecules as well as assembly into functional…
Role of inhibins and activins in ovarian cancer.
Cancer Treat Res. 2002;107:293-302
Authors: Woodruff TK
PMID: 11775457 [PubMed - indexed for MEDLINE]