Publications

An activin/furin regulatory loop modulates the processing and secretion of inhibin alpha- and betaB-subunit dimers in pituitary gonadotrope cells. J Biol Chem. 2008 Nov 28;283(48):33059-68 Authors: Antenos M, Zhu J, Jetly NM, Woodruff TK Abstract Of all ligands of the transforming growth factor beta superfamily, inhibins and activins are a…

Making eggs: is it now or later? Nat Med. 2008 Nov;14(11):1190-1 Authors: Woodruff TK PMID: 18989303 [PubMed - indexed for MEDLINE]

Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing. Fertil Steril. 2008 Oct;90(4):911-40 Authors: Crain DA, Janssen SJ, Edwards TM, Heindel J, Ho SM, Hunt P, Iguchi T, Juul A, McLachlan JA, Schwartz J, Skakkebaek N, Soto AM, Swan S, Walker C, Woodruff TK, Woodruff TJ, Giudice LC, Guillette LJ Abstract …

The role of activin A and Akt/GSK signaling in ovarian tumor biology. Endocrinology. 2008 Aug;149(8):3809-16 Authors: Do TV, Kubba LA, Antenos M, Rademaker AW, Sturgis CD, Woodruff TK Abstract Elevated activin A levels in serum, cyst fluid, and peritoneal fluid of ovarian cancer patients suggest a role for this peptide…

An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology. 2008 Jun;149(6):2970-9 Authors: Sinkevicius KW, Burdette JE, Woloszyn K, Hewitt SC, Hamilton K, Sugg SL, Temple KA, Wondisford FE, Korach KS, Woodruff TK, Greene GL Abstract Estrogen-nonresponsive estrogen receptor-alpha (ERalpha) knock-in…

Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition. Mol Cancer Res. 2008 May;6(5):695-705 Authors: Do TV, Kubba LA, Du H, Sturgis CD, Woodruff TK Abstract Transforming growth factor-beta (TGF-beta) is thought to play a role in the…

Fetal and early postnatal environmental exposures and reproductive health effects in the female. Fertil Steril. 2008 Feb;89(2 Suppl):e47-51 Authors: Woodruff TK, Walker CL Abstract This short review presents current research into the role of the environment in normal female reproductive function and pathogenesis, specifically focusing on the ovary and uterus.…

Smad3 and Pitx2 cooperate in stimulation of FSHbeta gene transcription. Mol Cell Endocrinol. 2008 Jan 16;281(1-2):27-36 Authors: Suszko MI, Antenos M, Balkin DM, Woodruff TK Abstract Activin is a member of the TGFbeta superfamily of growth and differentiation factors that control a variety of cellular and physiological functions. The canonical…