Regulation of cellular and system function by activin.
Biochem Pharmacol. 1998 Apr 1;55(7):953-63
Authors: Woodruff TK
Activin is an important molecule that regulates hormonogenesis, cellular homeostasis (divide or die pathways), and differentiation programs (developmentally and in adult cells). The cellular mechanisms that integrate an activin signal into a physiological response include a binary receptor complex and tandem serine…
Cellular localization of mRNA and protein: in situ hybridization histochemistry and in situ ligand binding.
Methods Cell Biol. 1998;57:333-51
Authors: Woodruff TK
Powerful methods for the detection of mRNA and proteins in cells and tissue sections have been developed since the mid-1980s. This chapter discusses the applications of in situ hybridization histochemistry and in situ ligand binding to…
Identification of an inhibin receptor in gonadal tumors from inhibin alpha-subunit knockout mice.
J Biol Chem. 1998 Jan 2;273(1):398-403
Authors: Draper LB, Matzuk MM, Roberts VJ, Cox E, Weiss J, Mather JP, Woodruff TK
Inhibins and activins are dimeric proteins that are functional antagonists and are structurally related to the transforming growth factor-beta (TGFbeta) family of growth and…