Betaglycan localization in the female rat pituitary: implications for the regulation of follicle-stimulating hormone by inhibin.
Endocrinology. 2003 Dec;144(12):5640-9
Authors: Chapman SC, Woodruff TK
Activin-stimulated FSH synthesis and secretion from the pituitary gonadotrope is negatively modulated by ovarian inhibin; however, the cellular mechanism of inhibin antagonism is unknown. Inhibin and activin share a common beta-subunit through which inhibin…
Novel approach for the three-dimensional culture of granulosa cell-oocyte complexes.
Tissue Eng. 2003 Oct;9(5):1013-21
Authors: Pangas SA, Saudye H, Shea LD, Woodruff TK
The in vitro culture of immature ovarian follicles is used to examine the factors that regulate follicle development and may ultimately provide options for reproductive infertility. The objective of this study was to develop a…
Murine granulosa cell morphology and function are regulated by a synthetic Arg-Gly-Asp matrix.
Mol Cell Endocrinol. 2003 Jul 31;205(1-2):1-10
Authors: Kreeger PK, Woodruff TK, Shea LD
Extracellular matrix (ECM) proteins are established regulators of granulosa cell survival, morphology, and differentiation. In this study, the roles of ECM adhesion peptide density on murine granulosa cell adhesion, morphology, and steroid…
Normal reproductive function in InhBP/p120-deficient mice.
Mol Cell Biol. 2003 Jul;23(14):4882-91
Authors: Bernard DJ, Burns KH, Haupt B, Matzuk MM, Woodruff TK
The inhibins are gonadal transforming growth factor beta superfamily protein hormones that suppress pituitary follicle-stimulating hormone (FSH) synthesis. Recently, betaglycan and inhibin binding protein (InhBP/p120, also known as the product of immunoglobulin superfamily gene 1 [IGSF1])…
Activin signal transduction in the fetal rat adrenal gland and in human H295R cells.
J Endocrinol. 2003 Jul;178(1):137-48
Authors: Wang EY, Ma EY, Woodruff TK
The presence of activin A and its effects have previously been documented in the adrenal gland, particularly in the human fetal adrenal gland and the rat adrenal gland. The primary signaling pathway of…
Down-regulation of activin, activin receptors, and Smads in high-grade breast cancer.
Cancer Res. 2003 Jul 1;63(13):3783-90
Authors: Jeruss JS, Sturgis CD, Rademaker AW, Woodruff TK
Activin and transforming growth factor (TGF)-beta, members of the TGF-beta superfamily of growth factors, have been implicated in both mammary gland development and breast carcinogenesis. TGF-beta is thought to be involved in the…
Localization of activin and inhibin subunits, receptors and SMADs in the mouse mammary gland.
Mol Cell Endocrinol. 2003 May 30;203(1-2):185-96
Authors: Jeruss JS, Santiago JY, Woodruff TK
Activin and inhibin, two closely related protein hormones, are members of the transforming growth factor beta (TGF beta) superfamily of growth factors. Activin and TGF beta have been associated with mouse…
Age-related analysis of inhibin A and B relative to the intercycle monotropic FSH rise in normal ovulatory women.
Ann Endocrinol (Paris). 2003 Apr;64(2):86
Authors: Houmard BS, Hansen KA, Woodruff TK, Sluss PM, Bremner WJ, Soules MR, Klein NA
PMID: 12773938 [PubMed - indexed for MEDLINE]
Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions.
EMBO J. 2003 Apr 1;22(7):1555-66
Authors: Thompson TB, Woodruff TK, Jardetzky TS
The TGF-beta superfamily of ligands and receptors stimulate cellular events in diverse processes ranging from cell fate specification in development to immune suppression. Activins define a major subgroup of TGF-beta ligands…
Regulation of the rat follicle-stimulating hormone beta-subunit promoter by activin.
Mol Endocrinol. 2003 Mar;17(3):318-32
Authors: Suszko MI, Lo DJ, Suh H, Camper SA, Woodruff TK
FSH is controlled by a variety of positive and negative stimuli, and the unique FSHbeta-subunit is a major target for this regulation. Activin is a key modulator of FSHbeta transcription and hormone secretion.…