Pediatric and Teen Ovarian Tissue Removed for Cryopreservation Contains Follicles Irrespective of Age, Disease Diagnosis, Treatment History, and Specimen Processing Methods.
J Adolesc Young Adult Oncol. 2015;4(4):174-83
Authors: Duncan FE, Pavone ME, Gunn AH, Badawy S, Gracia C, Ginsberg JP, Lockart B, Gosiengfiao Y, Woodruff TK
Abstract
PURPOSE: Fertility preservation in…
Primordial Follicle Transplantation within Designer Biomaterial Grafts Produce Live Births in a Mouse Infertility Model.
Sci Rep. 2015;5:17709
Authors: Kniazeva E, Hardy AN, Boukaidi SA, Woodruff TK, Jeruss JS, Shea LD
Abstract
The gonadotoxic effects of chemotherapy and radiation may result in premature ovarian failure in premenopausal oncology patients. Although autotransplantation…
New advances in ovarian autotransplantation to restore fertility in cancer patients.
Cancer Metastasis Rev. 2015 Nov 20;
Authors: Salama M, Woodruff TK
Abstract
Human ovary autotransplantation is a promising option for fertility preservation of young women and girls undergoing gonadotoxic treatments for cancer or some autoimmune diseases. Although experimental, it resulted…
Reproductive Endocrinologists' Utilization of Genetic Counselors for Oncofertility and Preimplantation Genetic Diagnosis (PGD) Treatment of BRCA1/2 Mutation Carriers.
J Genet Couns. 2015 Nov 14;
Authors: Goetsch AL, Wicklund C, Clayman ML, Woodruff TK
Abstract
Genetic counselors believe fertility preservation and preimplantation genetic diagnosis (PGD) discussions to be a part of their…
Geography of Follicle Formation in the Embryonic Mouse Ovary Impacts Activation Pattern during the First Wave of Folliculogenesis.
Biol Reprod. 2015 Aug 5;
Authors: Cordeiro MH, Kim SY, Ebbert K, Duncan FE, Ramalho-Santos J, Woodruff TK
Abstract
During embryonic development mouse female germ cells enter meiosis in an anterior to posterior…
Sex-based biomedical research policy needs an implementation plan.
Womens Health (Lond Engl). 2015 Aug 3;:1-4
Authors: Woodruff TK, Green S, Paller A, Schlosser BJ, Spring B, Castle M, Stock MC, Carnethon MR, Clark CT, Gerard E, Turek FW, Wisner KL, Wakschlag LS, Kibbe MR, Mendelson MA, Simon MA, Hansen NM, Kenton K, Garcia PM, Zee P, Ramsey-Goldman…
Oncofertility: A Grand Collaboration Between Reproductive Medicine and Oncology.
Reproduction. 2015 Jun 30;
Authors: Woodruff TK
Abstract
In 2007, I was asked by the University of Calgary to participate in a symposium called "Pushing the Boundaries - Advances That Will Change the World in 20 Years." My topic was oncofertility, a…
Size-specific follicle selection improves mouse oocyte reproductive outcomes.
Reproduction. 2015 Jun 26;
Authors: Xiao S, Duncan FE, Bai L, Nguyen CT, Shea LD, Woodruff TK
Abstract
Encapsulated in vitro follicle growth (eIVFG) has great potential to provide an additional fertility preservation option for young women and girls with cancer or other…
Virtual High Throughput Screening to identify novel activin antagonists.
J Med Chem. 2015 Jun 22;
Authors: Zhu J, Mishra RK, Schiltz G, Makanji Y, Scheidt KA, Mazar A, Woodruff TK
Abstract
Activin belongs to the TGFβ superfamily, which is associated with several disease conditions including cancer-related cachexia, preterm labor with delivery,…
Initiation of puberty in mice following decellularized ovary transplant.
Biomaterials. 2015 May;50:20-9
Authors: Laronda MM, Jakus AE, Whelan KA, Wertheim JA, Shah RN, Woodruff TK
Abstract
Clinical interventions to preserve fertility and restore hormone levels in female patients with therapy-induced ovarian failure are insufficient, particularly for pediatric cancer patients. Laparoscopic isolation…
The inorganic anatomy of the mammalian preimplantation embryo and the requirement of zinc during the first mitotic divisions.
Dev Dyn. 2015 Apr 22;
Authors: Kong BY, Duncan FE, Que EL, Xu Y, Vogt S, O'Halloran TV, Woodruff TK
Abstract
BACKGROUND: Zinc is the most abundant transition metal in the mammalian oocyte,…
Opinion: Sex inclusion in basic research drives discovery.
Proc Natl Acad Sci U S A. 2015 Apr 20;
Authors: Klein SL, Schiebinger L, Stefanick ML, Cahill L, Danska J, de Vries GJ, Kibbe MR, McCarthy MM, Mogil JS, Woodruff TK, Zucker I
PMID: 25902532 [PubMed - as supplied by publisher]
Engineering the ovarian cycle using in vitro follicle culture.
Hum Reprod. 2015 Mar 16;
Authors: Skory RM, Xu Y, Shea LD, Woodruff TK
Abstract
STUDY QUESTION: Can cultured follicles model the ovarian cycle, including follicular- and luteal-phase hormone synthesis patterns and ovulation?
SUMMARY ANSWER:…
Age-associated alterations in the micromechanical properties of chromosomes in the mammalian egg.
J Assist Reprod Genet. 2015 Mar 11;
Authors: Hornick JE, Duncan FE, Sun M, Kawamura R, Marko JF, Woodruff TK
Abstract
PURPOSE: The incidence of aneuploidy in eggs from women of advanced reproductive age can exceed 60 %, making the…
Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks.
Nat Chem. 2015 Feb;7(2):130-139
Authors: Que EL, Bleher R, Duncan FE, Kong BY, Gleber SC, Vogt S, Chen S, Garwin SA, Bayer AR, Dravid VP, Woodruff TK, O'Halloran TV
Abstract
Fertilization of a mammalian egg…
Use of an organotypic mammalian in vitro follicle growth assay to facilitate female reproductive toxicity screening.
Reprod Fertil Dev. 2015 Feb 18;
Authors: Xu Y, Duncan FE, Xu M, Woodruff TK
Abstract
Screening of pharmaceutical, chemical and environmental compounds for their effects on reproductive health relies on in vivo studies. More…
Novel Three Dimensional Human Endocervix Cultures respond to 28-day hormone treatment.
Endocrinology. 2015 Jan 30;:en20141840
Authors: Arslan SY, Yu Y, Burdette JE, Pavone ME, Hope TJ, Woodruff TK, Kim JJ
Abstract
The endocervix has both anatomical and biological functions that participate in the delicate balance between tolerance necessary for conception and…
Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles.
Endocrinology. 2015 Jan 16;:en20141926
Authors: Kim SY, Ebbert K, Cordeiro MH, Romero M, Zhu J, Ann Serna V, Whelan KA, Woodruff TK, Kurita T
Abstract
In this study, we explored the effects…