The development of a mouse model of ovarian endosalpingiosis.
Endocrinology. 2005 Dec;146(12):5228-36
Authors: Bristol-Gould SK, Hutten CG, Sturgis C, Kilen SM, Mayo KE, Woodruff TK
Pelvic pain is a common presenting ailment in women often linked to ovulation, endometriosis, early pregnancy, ovarian cancer, and cysts. Clear differential diagnosis for each condition caused by these varied etiologies is difficult…
Structural basis for a functional antagonist in the transforming growth factor beta superfamily.
J Biol Chem. 2005 Dec 2;280(48):40177-86
Authors: Cook RW, Thompson TB, Kurup SP, Jardetzky TS, Woodruff TK
Within the transforming growth factor beta superfamily, the agonist-antagonist relationship between activin and inhibin is unique and critical to integrated reproductive function. Activin acts in the pituitary to…
Regulation of mouse follicle development by follicle-stimulating hormone in a three-dimensional in vitro culture system is dependent on follicle stage and dose.
Biol Reprod. 2005 Nov;73(5):942-50
Authors: Kreeger PK, Fernandes NN, Woodruff TK, Shea LD
The developmental requirements of ovarian follicles are dependent on the maturation stage of the follicle; in particular, elegant studies with genetic models have…
The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding.
Dev Cell. 2005 Oct;9(4):535-43
Authors: Thompson TB, Lerch TF, Cook RW, Woodruff TK, Jardetzky TS
TGF-beta ligands stimulate diverse cellular differentiation and growth responses by signaling through type I and II receptors. Ligand antagonists, such as follistatin, block signaling and are…
A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling.
J Am Chem Soc. 2005 Sep 28;127(38):13164-6
Authors: Lee J, Zylka MJ, Anderson DJ, Burdette JE, Woodruff TK, Meade TJ
We have synthesized the first steroid hormone-MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has…
Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells.
Cancer Res. 2005 Sep 1;65(17):7968-75
Authors: Burdette JE, Jeruss JS, Kurley SJ, Lee EJ, Woodruff TK
The transforming growth factor-beta (TGF-beta) superfamily of growth factors is responsible for a variety of physiologic actions, including cell cycle regulation. Activin is a member of…
To beta or not to beta: estrogen receptors and ovarian function.
Endocrinology. 2005 Aug;146(8):3244-6
Authors: Woodruff TK, Mayo KE
PMID: 16009972 [PubMed - indexed for MEDLINE]
Smad3 mediates activin-induced transcription of follicle-stimulating hormone beta-subunit gene.
Mol Endocrinol. 2005 Jul;19(7):1849-58
Authors: Suszko MI, Balkin DM, Chen Y, Woodruff TK
Synthesis of FSH by the anterior pituitary is regulated by activin, a member of the FSH(beta) superfamily of ligands. Activin signals through a pathway that involves the activation of the transcriptional coregulators Smad2 and Smad3. Previous…
Induction of cyclin D2 in rat granulosa cells requires FSH-dependent relief from FOXO1 repression coupled with positive signals from Smad.
J Biol Chem. 2005 Mar 11;280(10):9135-48
Authors: Park Y, Maizels ET, Feiger ZJ, Alam H, Peters CA, Woodruff TK, Unterman TG, Lee EJ, Jameson JL, Hunzicker-Dunn M
Ovarian follicles undergo exponential growth in response to follicle-stimulating hormone (FSH),…