The primordial pool of follicles and nest breakdown in mammalian ovaries.
Mol Hum Reprod. 2009 Dec;15(12):795-803
Authors: Tingen C, Kim A, Woodruff TK
Abstract The creation of the pool of follicles available for selection and ovulation is a multi-faceted, tightly regulated process that spans the period from embryonic development through…
Characterization of the ovarian and reproductive abnormalities in prepubertal and adult estrogen non-responsive estrogen receptor alpha knock-in (ENERKI) mice.
Steroids. 2009 Nov;74(12):913-9
Authors: Sinkevicius KW, Woloszyn K, Laine M, Jackson KS, Greene GL, Woodruff TK, Burdette JE
Abstract Estrogen non-responsive estrogen receptor alpha (ERalpha) knock-in (ENERKI) mice have a mutation…
Rock the cradle.
Nat Med. 2009 Nov;15(11):1244
Authors: Woodruff TK
PMID: 19893551 [PubMed - in process]
Interpenetrating fibrin-alginate matrices for in vitro ovarian follicle development.
Biomaterials. 2009 Oct;30(29):5476-85
Authors: Shikanov A, Xu M, Woodruff TK, Shea LD
Abstract In this report, we investigate the fibrin-alginate interpenetrating network (FA-IPN) to provide dynamic cell-responsive mechanical properties, which we apply to the in vitro growth of ovarian follicles. The…
Preserving fertility during cancer treatment.
Nat Med. 2009 Oct;15(10):1124-5
Authors: Woodruff TK
PMID: 19812566 [PubMed - indexed for MEDLINE]
In vitro grown human ovarian follicles from cancer patients support oocyte growth.
Hum Reprod. 2009 Oct;24(10):2531-40
Authors: Xu M, Barrett SL, West-Farrell E, Kondapalli LA, Kiesewetter SE, Shea LD, Woodruff TK
Abstract BACKGROUND: Young female adult and adolescent cancer patients facing life-preserving but fertility-threatening chemo- or radiation-therapy are increasingly seeking…
Encapsulated three-dimensional culture supports development of nonhuman primate secondary follicles.
Encapsulated three-dimensional culture supports development of nonhuman primate secondary follicles.
Biol Reprod. 2009 Sep;81(3):587-94
Authors: Xu M, West-Farrell ER, Stouffer RL, Shea LD, Woodruff TK, Zelinski MB
Abstract In vitro ovarian follicle cultures may provide fertility-preserving options to women facing premature infertility due to cancer therapies. An encapsulated three-dimensional (3-D)…
Preserving female fertility following cancer treatment: current options and future possibilities.
Pediatr Blood Cancer. 2009 Aug;53(2):289-95
Authors: West ER, Zelinski MB, Kondapalli LA, Gracia C, Chang J, Coutifaris C, Critser J, Stouffer RL, Shea LD, Woodruff TK
Abstract Children and women of reproductive age are increasingly surviving cancer diagnoses, and…
Prepubertal primordial follicle loss in mice is not due to classical apoptotic pathways.
Biol Reprod. 2009 Jul;81(1):16-25
Authors: Tingen CM, Bristol-Gould SK, Kiesewetter SE, Wellington JT, Shea L, Woodruff TK
Abstract More than half of the primordial follicles that are formed by Day 6 of postnatal life in the mouse…
Secondary follicle growth and oocyte maturation by culture in alginate hydrogel following cryopreservation of the ovary or individual follicles.
Biotechnol Bioeng. 2009 Jun 1;103(2):378-86
Authors: Xu M, Banc A, Woodruff TK, Shea LD
Abstract An option for fertility preservation for women facing a cancer diagnosis involves the cryopreservation of ovarian…
Regulation of Wilms' tumor gene expression by nerve growth factor and follicle-stimulating hormone in the immature mouse ovary.
Fertil Steril. 2009 Apr;91(4 Suppl):1451-4
Authors: Roh J, Bae J, Lee K, Mayo K, Shea L, Woodruff TK
Abstract This study investigated the regulation of Wilms' tumor gene (WT1) in the ovary…
The mouse follicle microenvironment regulates antrum formation and steroid production: alterations in gene expression profiles.
Biol Reprod. 2009 Mar;80(3):432-9
Authors: West-Farrell ER, Xu M, Gomberg MA, Chow YH, Woodruff TK, Shea LD
Abstract Folliculogenesis is a coordinated process, and the genes that regulate development are difficult to investigate in vivo.…
Preservation of fertility in patients with cancer.
N Engl J Med. 2009 Feb 26;360(9):902-11
Authors: Jeruss JS, Woodruff TK
PMID: 19246362 [PubMed - indexed for MEDLINE]
Suppression of Notch signaling in the neonatal mouse ovary decreases primordial follicle formation.
Endocrinology. 2009 Feb;150(2):1014-24
Authors: Trombly DJ, Woodruff TK, Mayo KE
Abstract Notch signaling directs cell fate during embryogenesis by influencing cell proliferation, differentiation, and apoptosis. Notch genes are expressed in the adult mouse ovary, and roles for…
Roles for transforming growth factor beta superfamily proteins in early folliculogenesis.
Semin Reprod Med. 2009 Jan;27(1):14-23
Authors: Trombly DJ, Woodruff TK, Mayo KE
Abstract Primordial follicle formation and the subsequent transition of follicles to the primary and secondary stages encompass the early events during folliculogenesis in mammals. These processes establish…