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Creating a Global Community of Practice for Oncofertility

Creating a Global Community of Practice for Oncofertility JCO Glob Oncol. 2020 Nov;6:317-330 Authors: Ataman LM, Rodrigues JK, Marinho RM, Caetano JPJ, Chehin MB, Alves da Motta EL, Serafini P, Suzuki N, Furui T, Takae S, Sugishita Y, Morishige KI, Almeida-Santos T, Melo C, Buzaglo K, Irwin K, Wallace WH, Anderson RA, Mitchell RT, Telfer EE, Adiga SK,…

Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids

Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids J Vis Exp. 2020 Oct 7;(164) Authors: Edmonds ME, Forshee MD, Woodruff TK Abstract: Testicular organoids provide a tool for studying testicular development, spermatogenesis, and endocrinology in vitro. Several methods have been developed in order to create testicular organoids. Many of these methods rely upon extracellular matrix (ECM)…

A Tiered Female Ovarian Toxicity Screening Identifies Toxic Effects of Checkpoint Kinase 1 Inhibitors on Murine Growing Follicles

A Tiered Female Ovarian Toxicity Screening Identifies Toxic Effects of Checkpoint Kinase 1 Inhibitors on Murine Growing Follicles Toxicol Sci. 2020 Oct 1;177(2):405-419 Authors: Xu J, Wang Y, Kauffman AE, Zhang Y, Li Y, Zhu J, Maratea K, Fabre K, Zhang Q, Woodruff TK, Xiao S Abstract: Ovarian toxicity (ovotoxicity) is one of the major side effects of pharmaceutical compounds…

Exposure of human fallopian tube epithelium to elevated testosterone results in alteration of cilia gene expression and beating

Exposure of human fallopian tube epithelium to elevated testosterone results in alteration of cilia gene expression and beating Hum Reprod. 2020 Sep 1;35(9):2086-2096 Authors: Jackson-Bey T, Colina J, Isenberg BC, Coppeta J, Urbanek M, Kim JJ, Woodruff TK, Burdette JE, Russo A Abstract: Study question: How does exposure to a testosterone rich environment affect the function and gene expression of human…

Distinct follicular and luteal transcriptional profiles in engineered human ectocervical tissue dependent on menstrual cycle phase

Distinct follicular and luteal transcriptional profiles in engineered human ectocervical tissue dependent on menstrual cycle phase Biol. Reprod. 2020 Aug 21; 103(3):487-496 Authors: McKinnon KE, Getsios S, Woodruff TK Abstract: To investigate genomic pathways that may influence physiology and infectivity during the menstrual cycle, RNA sequence analysis was performed on patient-matched engineered ectocervical tissue after follicular and luteal phase (LP)…

Prospects of Rescuing Young Eggs for Oncofertility

Prospects of Rescuing Young Eggs for Oncofertility Trends Endocrinol Metab. 2020 Oct;31(10):708-711 Authors: Bertoldo MJ, Smitz J, Wu LE, Lee HC, Woodruff TK, Gilchrist RB Abstract: Childhood cancer patients undergoing cancer therapy can be rendered infertile during adulthood. With more girls surviving cancer, fertility preservation in young cancer patients is a major clinical challenge. Advances in egg culture may offer…

Proton Radiotherapy to Preserve Fertility and Endocrine Function: A Translational Investigation

Proton Radiotherapy to Preserve Fertility and Endocrine Function: A Translational Investigation. Int J Radiat Oncol Biol Phys. 2021 Jan 1;109(1):84-94 Authors: Gross JP, Kim SY, Gondi V, Pankuch M, Wagner S, Grover A, Luan Y, Woodruff TK Abstract: Purpose: Photon radiation therapy (x-ray radiation therapy [XRT] and gamma-ray radiation therapy [GRT]) of tumors close to ovaries causes reproductive and endocrine sequelae…

Zinc Dynamics during Drosophila Oocyte Maturation and Egg Activation

Zinc Dynamics during Drosophila Oocyte Maturation and Egg Activation iScience. 2020 Jul 24;23(7):101275 Authors: Hu Q, Duncan FE, Nowakowski AB, Antipova OA, Woodruff TK, O'Halloran TV, Wolfner MF Abstract: Temporal fluctuations in zinc concentration are essential signals, including during oogenesis and early embryogenesis. In mammals, zinc accumulation and release are required for oocyte maturation and egg activation, respectively. Here, we…

Installing oncofertility programs for common cancers in limited resource settings (Repro-Can-OPEN Study): An extrapolation during the global crisis of Coronavirus (COVID-19) pandemic.

Installing oncofertility programs for common cancers in limited resource settings (Repro-Can-OPEN Study): An extrapolation during the global crisis of Coronavirus (COVID-19) pandemic. J Assist Reprod Genet. 2020 Jun 27;: Authors: Salama M, Ataman-Millhouse L, Braham M, Berjeb K, Khrouf M, Rodrigues JK, Reis FM, Silva TC, Sánchez F, Romero S, Smitz J, Vásquez L, Vega M, Sobral…

Zinc Dynamics during Drosophila Oocyte Maturation and Egg Activation.

Zinc Dynamics during Drosophila Oocyte Maturation and Egg Activation. iScience. 2020 Jun 16;23(7):101275 Authors: Hu Q, Duncan FE, Nowakowski AB, Antipova OA, Woodruff TK, O'Halloran TV, Wolfner MF Abstract Temporal fluctuations in zinc concentration are essential signals, including during oogenesis and early embryogenesis. In mammals, zinc accumulation and release are required…

Testicular organoid formation is a property of immature somatic cells, which self-assemble and exhibit long-term hormone-responsive endocrine function.

Testicular organoid formation is a property of immature somatic cells, which self-assemble and exhibit long-term hormone-responsive endocrine function. Biofabrication. 2020 Jun 03;: Authors: Edmonds ME, Woodruff TK Abstract Testicular organoid models are tools to study testicular physiology, development, and spermatogenesisin vitro. However, few side-by-side comparisons of organoid generation method have been…

Counseling and surveillance of obstetric risks for female childhood, adolescent, and young adult cancer survivors: recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group.

Counseling and surveillance of obstetric risks for female childhood, adolescent, and young adult cancer survivors: recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Am J Obstet Gynecol. 2020 Jun 02;: Authors: van der Kooi ALF, Mulder RL, Hudson MM, Kremer LCM, Skinner R, Constine LS, van Dorp W, van Dulmen-den Broeder E, Winther…

Distinct follicular and luteal transcriptional profiles in engineered human ectocervical tissue dependent on menstrual cycle phase.

Distinct follicular and luteal transcriptional profiles in engineered human ectocervical tissue dependent on menstrual cycle phase. Biol Reprod. 2020 Apr 21;: Authors: McKinnon KE, Getsios S, Woodruff TK Abstract To investigate genomic pathways that may influence physiology and infectivity during the menstrual cycle, RNA sequence analysis was performed on patient-matched engineered…

Barriers and Opportunities of Oncofertility Practice in Nine Developing Countries and the Emerging Oncofertility Professional Engagement Network.

Barriers and Opportunities of Oncofertility Practice in Nine Developing Countries and the Emerging Oncofertility Professional Engagement Network. JCO Glob Oncol. 2020;6: Authors: Salama M, Ataman-Millhouse L, Sobral F, Terrado G, Scarella A, Bourlon MT, Adiga SK, Udupa KS, Mahajan N, Patil M, Venter C, Demetriou G, Quintana R, Rodriguez G, Quintana T, Viale L, Bonilla YAR, Noguera…

Building Oncofertility Core Competency in Developing Countries: Experience From Egypt, Tunisia, Brazil, Peru, and Panama.

Building Oncofertility Core Competency in Developing Countries: Experience From Egypt, Tunisia, Brazil, Peru, and Panama. JCO Glob Oncol. 2020;6: Authors: Salama M, Ataman L, Taha T, Azmy O, Braham M, Douik F, Khrouf M, Rodrigues JK, Reis FM, Sánchez F, Romero S, Vega M, Woodruff TK Abstract Purpose: Little is known…

Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe.

Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe. JCO Glob Oncol. 2020;6: Authors: Rashedi AS, de Roo SF, Ataman LM, Edmonds ME, Silva AA, Scarella A, Horbaczewska A, Anazodo A, Arvas A, Ramalho de Carvalho B, Sartorio C, Beerendonk CCM, Diaz-Garcia C, Suh CS, Melo C, Yding Andersen C, Motta E, Greenblatt…

Survey of Third-Party Parenting Options Associated With Fertility Preservation Available to Patients With Cancer Around the Globe.

Survey of Third-Party Parenting Options Associated With Fertility Preservation Available to Patients With Cancer Around the Globe. JCO Glob Oncol. 2020;6: Authors: Rashedi AS, de Roo SF, Ataman LM, Edmonds ME, Silva AA, Scarella A, Horbaczewska A, Anazodo A, Arvas A, Ramalho de Carvalho B, Sartorio C, Beerendonk CCM, Diaz-Garcia C, Suh CS, Melo C, Andersen CY,…

Engineered reproductive tissues.

Engineered reproductive tissues. Nat Biomed Eng. 2020 Apr 06;: Authors: Gargus ES, Rogers HB, McKinnon KE, Edmonds ME, Woodruff TK Abstract Engineered male and female biomimetic reproductive tissues are being developed as autonomous in vitro units or as integrated multi-organ in vitro systems to support germ cell and embryo function, and…