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The maternal-to-zygotic transition: An asynchronous split.

The maternal-to-zygotic transition: An asynchronous split. Mol Reprod Dev. 2012 Dec 4; Authors: Kong BY, Woodruff TK Abstract The early cell cycles of preimplantation embryo development are unique in the scheme of mitotic cell proliferation as cell division is not coupled to cell growth, leading to a halving of blastomere…

Evidence for Chromosome 2p16.3 Polycystic Ovary Syndrome Susceptibility Locus in Affected Women of European Ancestry.

Evidence for Chromosome 2p16.3 Polycystic Ovary Syndrome Susceptibility Locus in Affected Women of European Ancestry. J Clin Endocrinol Metab. 2012 Nov 1; Authors: Mutharasan P, Galdones E, Peñalver Bernabé B, Garcia OA, Jafari N, Shea LD, Woodruff TK, Legro RS, Dunaif A, Urbanek M Abstract Context:A previous genome-wide association study…

Bipolar-to-monopolar spindle collapse in human eggs.

Bipolar-to-monopolar spindle collapse in human eggs. Mol Reprod Dev. 2012 Jul 9; Authors: Duncan FE, Hornick JE, Woodruff TK Abstract The bipolar spindle is an integral part of the cell division machinery required for faithful chromosome segregation. During meiosis in the mammalian females, this machinery must function sequentially during a…

Quantification of anti-Mullerian hormone (AMH) in dried blood spots: validation of a minimally invasive method for assessing ovarian reserve.

Quantification of anti-Mullerian hormone (AMH) in dried blood spots: validation of a minimally invasive method for assessing ovarian reserve. Hum Reprod. 2012 Jun 6; Authors: McDade TW, Woodruff TK, Huang YY, Funk WE, Prewitt M, Kondapalli L, Gracia CR Abstract BACKGROUNDBiological markers of ovarian reserve have the potential to advance…

Isolated primate primordial follicles require a rigid physical environment to survive and grow in vitro.

Isolated primate primordial follicles require a rigid physical environment to survive and grow in vitro. Hum Reprod. 2012 Jun;27(6):1801-10 Authors: Hornick JE, Duncan FE, Shea LD, Woodruff TK Abstract BACKGROUND: In vitro follicle growth is a promising fertility preservation strategy in which ovarian follicles are cultured to produce mature and…

Embryonic fibroblasts enable the culture of primary ovarian follicles within alginate hydrogels.

Embryonic fibroblasts enable the culture of primary ovarian follicles within alginate hydrogels. Tissue Eng Part A. 2012 Jun;18(11-12):1229-38 Authors: Tagler D, Tu T, Smith RM, Anderson NR, Tingen CM, Woodruff TK, Shea LD Abstract Hydrogel-encapsulating culture systems support the consistent growth of ovarian follicles from various species, such as mouse,…

Age-associated alteration of oocyte-specific gene expression in polar bodies: potential markers of oocyte competence.

Age-associated alteration of oocyte-specific gene expression in polar bodies: potential markers of oocyte competence. Fertil Steril. 2012 May 24; Authors: Jiao ZX, Xu M, Woodruff TK Abstract OBJECTIVE: To confirm that oocyte-specific messenger RNAs are detectable in the polar body (PB) of metaphase II (MII) oocytes and determine the effect of age…

Improved fertility preservation care for male patients with cancer after establishment of formalized oncofertility program.

Improved fertility preservation care for male patients with cancer after establishment of formalized oncofertility program. J Urol. 2012 Mar;187(3):979-86 Authors: Sheth KR, Sharma V, Helfand BT, Cashy J, Smith K, Hedges JC, Köhler TS, Woodruff TK, Brannigan RE Abstract PURPOSE: Survival to reproductive age among men with cancer has steadily…

The possible role of resource requirements and academic career-choice risk on gender differences in publication rate and impact.

The possible role of resource requirements and academic career-choice risk on gender differences in publication rate and impact. PLoS One. 2012;7(12):e51332 Authors: Duch J, Zeng XH, Sales-Pardo M, Radicchi F, Otis S, Woodruff TK, Nunes Amaral LA Abstract Many studies demonstrate that there is still a significant gender bias, especially at higher career levels, in many areas including science,…

Fibrin encapsulation and vascular endothelial growth factor delivery promotes ovarian graft survival in mice.

Fibrin encapsulation and vascular endothelial growth factor delivery promotes ovarian graft survival in mice. Tissue Eng Part A. 2011 Dec;17(23-24):3095-104 Authors: Shikanov A, Zhang Z, Xu M, Smith RM, Rajan A, Woodruff TK, Shea LD Abstract Ovarian cryopreservation before chemotherapy and autotransplantation post-treatment can restore fertility to women with premature…

Creating a continuum of care: integrating obstetricians and gynecologists in the care of young cancer patients.

Creating a continuum of care: integrating obstetricians and gynecologists in the care of young cancer patients. Clin Obstet Gynecol. 2011 Dec;54(4):619-32 Authors: Kong BY, Skory RM, Woodruff TK Abstract Cancer therapy can be lifesaving but significantly diminish female reproductive potential. This review provides an overview of the deleterious effects…

Altered gonadal expression of TGF-β superfamily signaling factors in environmental contaminant-exposed juvenile alligators.

Altered gonadal expression of TGF-β superfamily signaling factors in environmental contaminant-exposed juvenile alligators. J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):58-63 Authors: Moore BC, Milnes MR, Kohno S, Katsu Y, Iguchi T, Woodruff TK, Guillette LJ Abstract Environmental contaminant exposure can influence gonadal steroid signaling milieus; however, little research has investigated…

Nonmalignant diseases and treatments associated with primary ovarian failure: an expanded role for fertility preservation.

Nonmalignant diseases and treatments associated with primary ovarian failure: an expanded role for fertility preservation. J Womens Health (Larchmt). 2011 Oct;20(10):1467-77 Authors: Hirshfeld-Cytron J, Gracia C, Woodruff TK Abstract Cancer treatments can be detrimental to fertility; recent literature has focused on the efforts of fertility preservation for this patient population.…

Animal age, weight and estrus cycle stage impact the quality of in vitro grown follicles.

Animal age, weight and estrus cycle stage impact the quality of in vitro grown follicles. Hum Reprod. 2011 Sep;26(9):2473-85 Authors: Hirshfeld-Cytron JE, Duncan FE, Xu M, Jozefik JK, Shea LD, Woodruff TK Abstract BACKGROUND: Ovarian tissue cryopreservation is an emerging fertility preservation option, and culturing follicles isolated from this tissue…

A truncated, activin-induced Smad3 isoform acts as a transcriptional repressor of FSHβ expression in mouse pituitary.

A truncated, activin-induced Smad3 isoform acts as a transcriptional repressor of FSHβ expression in mouse pituitary. Mol Cell Endocrinol. 2011 Aug 6;342(1-2):64-72 Authors: Kim SY, Zhu J, Woodruff TK Abstract The receptor-regulated protein Smad3 is key player in the signaling cascade stimulated by the binding of activin to its cell…

Gene expression in mouse ovarian follicle development in vivo versus an ex vivo alginate culture system.

Gene expression in mouse ovarian follicle development in vivo versus an ex vivo alginate culture system. Reproduction. 2011 Aug;142(2):309-18 Authors: Parrish EM, Siletz A, Xu M, Woodruff TK, Shea LD Abstract Ovarian follicle maturation results from a complex interplay of endocrine, paracrine, and direct cell-cell interactions. This study compared the…