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In vitro growth and steroidogenesis of dog follicles are influenced by the physical and hormonal microenvironment.

In vitro growth and steroidogenesis of dog follicles are influenced by the physical and hormonal microenvironment. Reproduction. 2011 Jul;142(1):113-22 Authors: Songsasen N, Woodruff TK, Wildt DE Abstract The present study examined the influences of the physical and hormonal microenvironment on in vitro growth and steroidogenesis of dog follicles. Follicles were…

A macrophage and theca cell-enriched stromal cell population influences growth and survival of immature murine follicles in vitro.

A macrophage and theca cell-enriched stromal cell population influences growth and survival of immature murine follicles in vitro. Reproduction. 2011 Jun;141(6):809-20 Authors: Tingen CM, Kiesewetter SE, Jozefik J, Thomas C, Tagler D, Shea L, Woodruff TK Abstract Innovations in in vitro ovarian follicle culture have revolutionized the field of fertility…

In vitro oocyte maturation and preantral follicle culture from the luteal-phase baboon ovary produce mature oocytes.

In vitro oocyte maturation and preantral follicle culture from the luteal-phase baboon ovary produce mature oocytes. Biol Reprod. 2011 Apr;84(4):689-97 Authors: Xu M, Fazleabas AT, Shikanov A, Jackson E, Barrett SL, Hirshfeld-Cytron J, Kiesewetter SE, Shea LD, Woodruff TK Abstract Female cancer patients who seek fertility preservation but cannot undergo…

Hydrogel network design using multifunctional macromers to coordinate tissue maturation in ovarian follicle culture.

Hydrogel network design using multifunctional macromers to coordinate tissue maturation in ovarian follicle culture. Biomaterials. 2011 Apr;32(10):2524-31 Authors: Shikanov A, Smith RM, Xu M, Woodruff TK, Shea LD Abstract Synthetic hydrogels with tunable properties are appealing for regenerative medicine. A critical limitation in hydrogel design at low solids concentration is…

Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-beta binding.

Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-beta binding. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5232-6 Authors: Lin SJ, Hu Y, Zhu J, Woodruff TK, Jardetzky TS Abstract The zona pellucida (ZP) domain is a bipartite protein structural element comprised…

Zinc requirement during meiosis I-meiosis II transition in mouse oocytes is independent of the MOS-MAPK pathway.

Zinc requirement during meiosis I-meiosis II transition in mouse oocytes is independent of the MOS-MAPK pathway. Biol Reprod. 2011 Mar;84(3):526-36 Authors: Bernhardt ML, Kim AM, O'Halloran TV, Woodruff TK Abstract Zinc is essential for many biological processes, including proper functioning of gametes. We recently reported that zinc levels rise by…

Results from the survey for preservation of adolescent reproduction (SPARE) study: gender disparity in delivery of fertility preservation message to adolescents with cancer.

Results from the survey for preservation of adolescent reproduction (SPARE) study: gender disparity in delivery of fertility preservation message to adolescents with cancer. J Assist Reprod Genet. 2011 Mar;28(3):269-77 Authors: Köhler TS, Kondapalli LA, Shah A, Chan S, Woodruff TK, Brannigan RE Abstract PURPOSE: Diminished reproductive capacity is a devastating…

Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin α- and β-subunits as candidate substrates.

Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin α- and β-subunits as candidate substrates. PLoS One. 2011;6(3):e17348 Authors: Antenos M, Lei L, Xu M, Malipatil A, Kiesewetter S, Woodruff TK Abstract Inhibin and activin are essential dimeric glycoproteins belonging to the transforming growth factor-beta (TGFβ)…

A new hypothesis regarding ovarian follicle development: ovarian rigidity as a regulator of selection and health.

A new hypothesis regarding ovarian follicle development: ovarian rigidity as a regulator of selection and health. J Assist Reprod Genet. 2011 Jan;28(1):3-6 Authors: Woodruff TK, Shea LD Abstract The mammalian ovary consists of a large number of dormant immature follicles, each containing a single oocyte and located on the periphery…

Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation.

Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation. Hum Reprod Update. 2010 Jul-Aug;16(4):395-414 Authors: Smitz J, Dolmans MM, Donnez J, Fortune JE, Hovatta O, Jewgenow K, Picton HM, Plancha C, Shea LD, Stouffer RL, Telfer EE, Woodruff TK, Zelinski MB Abstract BACKGROUND Female cancer patients are offered…

Sex and sensitivity: the continued need for sex-based biomedical research and implementation.

Sex and sensitivity: the continued need for sex-based biomedical research and implementation. Womens Health (Lond Engl). 2010 Jul;6(4):511-6 Authors: Tingen CM, Kim AM, Wu PH, Woodruff TK Abstract The phrase 'women's health research' embraces women as part of the biomedical research engine while categorizing women as separate. Before personalized medicine…

Markers of growth and development in primate primordial follicles are preserved after slow cryopreservation.

Markers of growth and development in primate primordial follicles are preserved after slow cryopreservation. Fertil Steril. 2010 May 15;93(8):2627-32 Authors: Jin S, Lei L, Shea LD, Zelinski MB, Stouffer RL, Woodruff TK Abstract OBJECTIVE: To investigate the effect of slow cryopreservation on the morphology and function of primate primordial follicles…