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Using decision trees to enhance interdisciplinary team work: the case of oncofertility.

Using decision trees to enhance interdisciplinary team work: the case of oncofertility. J Assist Reprod Genet. 2010 May;27(5):227-31 Authors: Gardino SL, Jeruss JS, Woodruff TK Abstract PURPOSE: Oncofertility, an emerging discipline at the intersection of cancer and fertility, strives to give cancer patients options when they are confronting potential infertility…

Altered sex hormone concentrations and gonadal mRNA expression levels of activin signaling factors in hatchling alligators from a contaminated Florida lake.

Altered sex hormone concentrations and gonadal mRNA expression levels of activin signaling factors in hatchling alligators from a contaminated Florida lake. J Exp Zool A Ecol Genet Physiol. 2010 Apr 1;313(4):218-30 Authors: Moore BC, Kohno S, Cook RW, Alvers AL, Hamlin HJ, Woodruff TK, Guillette LJ Abstract Activins and estrogens…

The Illinois Women's Health Registry: advancing women's health research and education in Illinois, USA.

The Illinois Women's Health Registry: advancing women's health research and education in Illinois, USA. Womens Health (Lond Engl). 2010 Mar;6(2):183-96 Authors: Bristol-Gould S, Desjardins M, Woodruff TK Abstract To achieve the goal of personalized medicine, we must first improve our understanding of the differences in health and illness between men…

The interactions between the stimulatory effect of follicle-stimulating hormone and the inhibitory effect of estrogen on mouse primordial folliculogenesis.

The interactions between the stimulatory effect of follicle-stimulating hormone and the inhibitory effect of estrogen on mouse primordial folliculogenesis. Biol Reprod. 2010 Jan;82(1):13-22 Authors: Lei L, Jin S, Mayo KE, Woodruff TK Abstract The murine primordial follicle pool develops largely within 3 days after birth through germline nest breakdown and…

Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist.

Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist. PLoS One. 2010;5(3):e9457 Authors: Zhu J, Braun EL, Kohno S, Antenos M, Xu EY, Cook RW, Lin SJ, Moore BC, Guillette LJ, Jardetzky TS, Woodruff TK Abstract Transforming growth factor-beta (TGFbeta) homologues form a diverse…

Characterization of the ovarian and reproductive abnormalities in prepubertal and adult estrogen non-responsive estrogen receptor alpha knock-in (ENERKI) mice.

Characterization of the ovarian and reproductive abnormalities in prepubertal and adult estrogen non-responsive estrogen receptor alpha knock-in (ENERKI) mice. Steroids. 2009 Nov;74(12):913-9 Authors: Sinkevicius KW, Woloszyn K, Laine M, Jackson KS, Greene GL, Woodruff TK, Burdette JE Abstract Estrogen non-responsive estrogen receptor alpha (ERalpha) knock-in (ENERKI) mice have a mutation…

In vitro grown human ovarian follicles from cancer patients support oocyte growth.

In vitro grown human ovarian follicles from cancer patients support oocyte growth. Hum Reprod. 2009 Oct;24(10):2531-40 Authors: Xu M, Barrett SL, West-Farrell E, Kondapalli LA, Kiesewetter SE, Shea LD, Woodruff TK Abstract BACKGROUND: Young female adult and adolescent cancer patients facing life-preserving but fertility-threatening chemo- or radiation-therapy are increasingly seeking…

Interpenetrating fibrin-alginate matrices for in vitro ovarian follicle development.

Interpenetrating fibrin-alginate matrices for in vitro ovarian follicle development. Biomaterials. 2009 Oct;30(29):5476-85 Authors: Shikanov A, Xu M, Woodruff TK, Shea LD Abstract In this report, we investigate the fibrin-alginate interpenetrating network (FA-IPN) to provide dynamic cell-responsive mechanical properties, which we apply to the in vitro growth of ovarian follicles. The…

Encapsulated three-dimensional culture supports development of nonhuman primate secondary follicles.

Encapsulated three-dimensional culture supports development of nonhuman primate secondary follicles. Biol Reprod. 2009 Sep;81(3):587-94 Authors: Xu M, West-Farrell ER, Stouffer RL, Shea LD, Woodruff TK, Zelinski MB Abstract In vitro ovarian follicle cultures may provide fertility-preserving options to women facing premature infertility due to cancer therapies. An encapsulated three-dimensional (3-D)…

Preserving female fertility following cancer treatment: current options and future possibilities.

Preserving female fertility following cancer treatment: current options and future possibilities. Pediatr Blood Cancer. 2009 Aug;53(2):289-95 Authors: West ER, Zelinski MB, Kondapalli LA, Gracia C, Chang J, Coutifaris C, Critser J, Stouffer RL, Shea LD, Woodruff TK Abstract Children and women of reproductive age are increasingly surviving cancer diagnoses, and…

Secondary follicle growth and oocyte maturation by culture in alginate hydrogel following cryopreservation of the ovary or individual follicles.

Secondary follicle growth and oocyte maturation by culture in alginate hydrogel following cryopreservation of the ovary or individual follicles. Biotechnol Bioeng. 2009 Jun 1;103(2):378-86 Authors: Xu M, Banc A, Woodruff TK, Shea LD Abstract An option for fertility preservation for women facing a cancer diagnosis involves the cryopreservation of ovarian…

Regulation of Wilms' tumor gene expression by nerve growth factor and follicle-stimulating hormone in the immature mouse ovary.

Regulation of Wilms' tumor gene expression by nerve growth factor and follicle-stimulating hormone in the immature mouse ovary. Fertil Steril. 2009 Apr;91(4 Suppl):1451-4 Authors: Roh J, Bae J, Lee K, Mayo K, Shea L, Woodruff TK Abstract This study investigated the regulation of Wilms' tumor gene (WT1) in the ovary…