Localization of activin and inhibin subunits, receptors and SMADs in the mouse mammary gland.
Mol Cell Endocrinol. 2003 May 30;203(1-2):185-96
Authors: Jeruss JS, Santiago JY, Woodruff TK
Activin and inhibin, two closely related protein hormones, are members of the transforming growth factor beta (TGF beta) superfamily of growth factors. Activin and TGF beta have been associated with mouse…
Age-related analysis of inhibin A and B relative to the intercycle monotropic FSH rise in normal ovulatory women.
Ann Endocrinol (Paris). 2003 Apr;64(2):86
Authors: Houmard BS, Hansen KA, Woodruff TK, Sluss PM, Bremner WJ, Soules MR, Klein NA
PMID: 12773938 [PubMed - indexed for MEDLINE]
Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions.
EMBO J. 2003 Apr 1;22(7):1555-66
Authors: Thompson TB, Woodruff TK, Jardetzky TS
The TGF-beta superfamily of ligands and receptors stimulate cellular events in diverse processes ranging from cell fate specification in development to immune suppression. Activins define a major subgroup of TGF-beta ligands…
Regulation of the rat follicle-stimulating hormone beta-subunit promoter by activin.
Mol Endocrinol. 2003 Mar;17(3):318-32
Authors: Suszko MI, Lo DJ, Suh H, Camper SA, Woodruff TK
FSH is controlled by a variety of positive and negative stimuli, and the unique FSHbeta-subunit is a major target for this regulation. Activin is a key modulator of FSHbeta transcription and hormone secretion.…
Smad4 overexpression causes germ cell ablation and leydig cell hyperplasia in transgenic mice.
Am J Pathol. 2002 Nov;161(5):1723-34
Authors: Narula A, Kilen S, Ma E, Kroeger J, Goldberg E, Woodruff TK
Members of the transforming growth factor-beta (TGF-beta) superfamily play a variety of important roles in testicular development and function. The tumor suppressor gene, Smad4, is a common…
Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors.
Mol Cell Endocrinol. 2002 Oct 31;196(1-2):79-93
Authors: Chapman SC, Bernard DJ, Jelen J, Woodruff TK
Activin-stimulated FSH synthesis and release by the pituitary gonadotrope is antagonized by gonadally derived inhibins. The two isoforms of inhibin, inhibin A and B, bind to the activin type II…
Photoperiod-dependent regulation of inhibin in Siberian hamsters: II. Regulation of inhibin production and secretion by pregnant mare serum gonadotropin.
J Endocrinol. 2002 Jul;174(1):85-94
Authors: Kenny HA, Bernard DJ, Horton TH, Woodruff TK
Inhibin production differs in ovaries of Siberian hamsters (Phodopus sungorus) exposed to long days (LD) or short days (SD). We believe that seasonal differences in serum…
Photoperiod-dependent regulation of inhibin in Siberian hamsters: I. Ovarian inhibin production and secretion.
J Endocrinol. 2002 Jul;174(1):71-83
Authors: Kenny HA, Bernard DJ, Horton TH, Woodruff TK
Follicle-stimulating hormone (FSH) stimulates ovarian follicle development and the production of protein hormones including inhibin A and inhibin B. The inhibins are dimeric proteins (alpha-beta(A) or alpha-beta(B)) secreted by growing follicles that…
Localization of the activin signal transduction components in normal human ovarian follicles: implications for autocrine and paracrine signaling in the ovary.
J Clin Endocrinol Metab. 2002 Jun;87(6):2644-57
Authors: Pangas SA, Rademaker AW, Fishman DA, Woodruff TK
The intraovarian function of gonadally produced activin is unclear, and many in vitro studies have suggested a role for activin in follicle…
Follistatin-free activin A is not associated with preterm birth.
Am J Obstet Gynecol. 2002 Mar;186(3):464-9
Authors: Wang EY, Woodruff TK, Moawad A,
OBJECTIVE: The purpose of this study was to determine whether follistatin-free activin A (an inhibin-related protein with rising serum levels before term labor) is associated with spontaneous preterm birth in an outpatient population. STUDY…
Inhibin binding protein (InhBP/p120), betaglycan, and the continuing search for the inhibin receptor.
Mol Endocrinol. 2002 Feb;16(2):207-12
Authors: Bernard DJ, Chapman SC, Woodruff TK
Betaglycan (the TGFbeta type III receptor) and InhBP/p120 (a membrane-tethered proteoglycan) were recently identified as putative inhibin receptors. Here, we review the current state of knowledge regarding these two proteins with respect to their…
Role of inhibins and activins in ovarian cancer.
Cancer Treat Res. 2002;107:293-302
Authors: Woodruff TK
PMID: 11775457 [PubMed - indexed for MEDLINE]
Production and purification of recombinant human inhibin and activin.
J Endocrinol. 2002 Jan;172(1):199-210
Authors: Pangas SA, Woodruff TK
Inhibin and activin are protein hormones with diverse physiological roles including the regulation of pituitary FSH secretion. Like other members of the transforming growth factor-beta gene family, they undergo processing from larger precursor molecules as well as assembly into functional…
An emerging role for co-receptors in inhibin signal transduction.
Mol Cell Endocrinol. 2001 Jun 30;180(1-2):55-62
Authors: Bernard DJ, Chapman SC, Woodruff TK
While many transforming growth factor-beta (TGFbeta) superfamily ligands such as TGFbeta, activin, and the bone morphogenic proteins (BMPs) are critical to the control of growth, differentiation, and cell fate, inhibin has a more limited role and…
Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).
Mol Endocrinol. 2001 Apr;15(4):668-79
Authors: Chapman SC, Woodruff TK
An antagonistic relationship between inhibin and activin is essential to the control of pituitary FSH release and to normal gonadal function. Two inhibin ligands, inhibin A and inhibin B, are made by the ovary in females, and…
Inhibin binding protein in rats: alternative transcripts and regulation in the pituitary across the estrous cycle.
Mol Endocrinol. 2001 Apr;15(4):654-67
Authors: Bernard DJ, Woodruff TK
Inhibin binding protein (InhBP) and the transforming growth factor-beta (TGF beta) type III receptor, beta glycan, have been identified as putative inhibin coreceptors. Here we cloned the InhBP cDNA in rats and predict…
Mechanisms of inhibin signal transduction.
Recent Prog Horm Res. 2001;56:417-50
Authors: Bernard DJ, Chapman SC, Woodruff TK
Inhibin was first identified as a gonadal hormone that potently inhibits pituitary follicle-stimulating hormone (FSH) synthesis and secretion. Although the notion of a nonsteroidal, gonadally derived inhibitory substance was realized in the early 1930s (McCullagh, 1932), identification of the hormone was…
Ovarian follicular concentrations of activin, follistatin, inhibin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-2 (IGFBP-2), IGFBP-3, and vascular endothelial growth factor in spontaneous menstrual cycles of normal women of advanced reproductive age.
J Clin Endocrinol Metab. 2000 Dec;85(12):4520-5
Authors: Klein NA, Battaglia DE, Woodruff TK, Padmanabhan V, Giudice LC, Bremner WJ, Soules MR
Previous studies indicate that…
Activin signal transduction pathways.
Trends Endocrinol Metab. 2000 Oct;11(8):309-14
Authors: Pangas SA, Woodruff TK
Many of the signal transduction pathways required for mammalian endocrine cell function are conserved from flies and worms. These model organisms permitted the illumination of the biological properties of ligands and provided systems in which cellular coactivating molecules could be identified rapidly. Our knowledge…
Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions.
Nat Genet. 2000 Aug;25(4):453-7
Authors: Brown CW, Houston-Hawkins DE, Woodruff TK, Matzuk MM
The activins (dimers of betaA or betaB subunits, encoded by the genes Inhba and Inhbb, respectively) are TGF-beta superfamily members that have roles in reproduction and development. Whereas mice…
Structure and expression of a membrane component of the inhibin receptor system.
Endocrinology. 2000 Jul;141(7):2600-7
Authors: Chong H, Pangas SA, Bernard DJ, Wang E, Gitch J, Chen W, Draper LB, Cox ET, Woodruff TK
The purification and cloning of a membrane-anchored proteoglycan with affinity for inhibin A are described. Bovine pituitary membranes were isolated, and membrane-anchored proteins were…
Activin A-induced HepG2 liver cell apoptosis: involvement of activin receptors and smad proteins.
Endocrinology. 2000 Mar;141(3):1263-72
Authors: Chen W, Woodruff TK, Mayo KE
A balance between cell proliferation and apoptosis is important for regulating normal liver function. Proteins of the transforming growth factor-beta superfamily are known to be important mediators of apoptosis in the liver. In this study…
Transgenic models to study gonadotropin function: the role of follicle-stimulating hormone in gonadal growth and tumorigenesis.
Mol Endocrinol. 1999 Jun;13(6):851-65
Authors: Kumar TR, Palapattu G, Wang P, Woodruff TK, Boime I, Byrne MC, Matzuk MM
The role of FSH in gonadal tumorigenesis and, in particular, in human ovarian cancer has been debated. It is also unclear what role…
Preoperative serum level of inhibin A is an independent prognostic factor for the survival of postmenopausal women with epithelial ovarian carcinoma.
Cancer. 1999 Jan 15;85(2):465-71
Authors: Frias AE, Li H, Keeney GL, Podratz KC, Woodruff TK
BACKGROUND: The aim of this study was to determine the prognostic significance of preoperative serum inhibin and activin levels in postmenopausal women…