Fertility preservation and adolescent cancer patients: lessons from adult survivors of childhood cancer and their parents.
Cancer Treat Res. 2007;138:201-17
Authors: Nieman CL, Kinahan KE, Yount SE, Rosenbloom SK, Yost KJ, Hahn EA, Volpe T, Dilley KJ, Zoloth L, Woodruff TK
PMID: 18080667 [PubMed - indexed for MEDLINE]
The emergence of a new interdiscipline: oncofertility.
Cancer Treat Res. 2007;138:3-11
Authors: Woodruff TK
PMID: 18080653 [PubMed - indexed for MEDLINE]
Oncofertility consortium consensus statement: guidelines for ovarian tissue cryopreservation.
Cancer Treat Res. 2007;138:235-9
Authors: Backhus LE, Kondapalli LA, Chang RJ, Coutifaris C, Kazer R, Woodruff TK
PMID: 18080669 [PubMed - indexed for MEDLINE]
Bioengineering and the ovarian follicle.
Cancer Treat Res. 2007;138:75-82
Authors: Xu M, Woodruff TK, Shea LD
PMID: 18080658 [PubMed - indexed for MEDLINE]
Identification of a stage-specific permissive in vitro culture environment for follicle growth and oocyte development.
Biol Reprod. 2006 Dec;75(6):916-23
Authors: Xu M, West E, Shea LD, Woodruff TK
Abstract The availability of viable oocytes is the limiting factor in the development of new reproductive techniques. Many attempts have been made…
Distribution of extracellular matrix proteins type I collagen, type IV collagen, fibronectin, and laminin in mouse folliculogenesis.
Histochem Cell Biol. 2006 Nov;126(5):583-92
Authors: Berkholtz CB, Lai BE, Woodruff TK, Shea LD
Abstract The extracellular matrix (ECM) plays a prominent role in ovarian function by participating in processes such as cell…
Tissue-engineered follicles produce live, fertile offspring.
Tissue Eng. 2006 Oct;12(10):2739-46
Authors: Xu M, Kreeger PK, Shea LD, Woodruff TK
Abstract Oocytes grown in vitro are of low quality and yield few live births, thus limiting the ability to store or bank the ova of women wishing to preserve their fertility.…
Postnatal regulation of germ cells by activin: the establishment of the initial follicle pool.
Dev Biol. 2006 Oct 1;298(1):132-48
Authors: Bristol-Gould SK, Kreeger PK, Selkirk CG, Kilen SM, Cook RW, Kipp JL, Shea LD, Mayo KE, Woodruff TK
Abstract Mammalian females enter puberty with follicular reserves that exceed the number…
Fate of the initial follicle pool: empirical and mathematical evidence supporting its sufficiency for adult fertility.
Dev Biol. 2006 Oct 1;298(1):149-54
Authors: Bristol-Gould SK, Kreeger PK, Selkirk CG, Kilen SM, Mayo KE, Shea LD, Woodruff TK
Abstract The importance of the initial follicle pool in fertility in female adult mammals…
Extracellular matrix functions in follicle maturation.
Semin Reprod Med. 2006 Sep;24(4):262-9
Authors: Berkholtz CB, Shea LD, Woodruff TK
Abstract The extracellular matrix (ECM) promotes and/or inhibits many cellular processes, including but not limited to proliferation, differentiation, and survival, which must occur for follicle growth and oocyte maturation. The ECM regulation…
The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding.
Reproduction. 2006 Aug;132(2):179-90
Authors: Lin SJ, Lerch TF, Cook RW, Jardetzky TS, Woodruff TK
Abstract The transforming growth factor-beta (TGF-beta) superfamily is a large group of structurally related growth factors that play prominent roles in a variety of…
Folliculogenesis in the domestic cat (Felis catus).
Theriogenology. 2006 Jul 1;66(1):5-13
Authors: Bristol-Gould S, Woodruff TK
The dynamic regulation of mammalian folliculogenesis is a key component of the reproductive process. Traditionally, the rodent had been used as a model to study ovarian function and reproductive physiology due to the availability of animals, their relatively short cycle length, high…
The expression of inhibin beta B is high in human adipocytes, reduced by weight loss, and correlates to factors implicated in metabolic disease.
Biochem Biophys Res Commun. 2006 Jun 16;344(4):1308-14
Authors: Sjöholm K, Palming J, Lystig TC, Jennische E, Woodruff TK, Carlsson B, Carlsson LM
Adipose tissue is an endocrine organ that produces and secretes adipokines. The aim…
Cell-specificity of transforming growth factor-beta response is dictated by receptor bioavailability.
J Mol Endocrinol. 2006 Jun;36(3):591-600
Authors: Suszko MI, Woodruff TK
Abstract Members of the transforming growth factor-beta (TGFbeta) family control diverse cellular responses including differentiation, proliferation, controlled cell death and migration. The response of a cell to an individual…
Gonadotropin-induced superovulation drives ovarian surface epithelia proliferation in CD1 mice.
Endocrinology. 2006 May;147(5):2338-45
Authors: Burdette JE, Kurley SJ, Kilen SM, Mayo KE, Woodruff TK
The ovarian surface epithelium (OSE) is a monolayer of cells that surround the ovary and accommodate repeated tear and repair in response to ovulation. OSE cells are thought to be the progenitors of 90%…
Cancer survivors and infertility: a review of a new problem and novel answers.
J Support Oncol. 2006 Apr;4(4):171-8
Authors: Nieman CL, Kazer R, Brannigan RE, Zoloth LS, Chase-Lansdale PL, Kinahan K, Dilley KJ, Roberts D, Shea LD, Woodruff TK
Abstract Improvements in cancer treatment have changed the way in which…
The in vitro regulation of ovarian follicle development using alginate-extracellular matrix gels.
Biomaterials. 2006 Feb;27(5):714-23
Authors: Kreeger PK, Deck JW, Woodruff TK, Shea LD
The extracellular matrix (ECM) provides a three-dimensional structure that promotes and regulates cell adhesion and provides signals that direct the cellular processes leading to tissue development. In this report, synthetic matrices that present defined…
Follicle size class contributes to distinct secretion patterns of inhibin isoforms during the rat estrous cycle.
Endocrinology. 2006 Jan;147(1):51-60
Authors: Kenny HA, Woodruff TK
The differential production of inhibins must be exquisitely controlled at the cellular level to ensure the secretion of the appropriate ligand at specific times during the reproductive cycle. The mechanisms underlying inhibin dimer assembly,…
The development of a mouse model of ovarian endosalpingiosis.
Endocrinology. 2005 Dec;146(12):5228-36
Authors: Bristol-Gould SK, Hutten CG, Sturgis C, Kilen SM, Mayo KE, Woodruff TK
Pelvic pain is a common presenting ailment in women often linked to ovulation, endometriosis, early pregnancy, ovarian cancer, and cysts. Clear differential diagnosis for each condition caused by these varied etiologies is difficult…
Structural basis for a functional antagonist in the transforming growth factor beta superfamily.
J Biol Chem. 2005 Dec 2;280(48):40177-86
Authors: Cook RW, Thompson TB, Kurup SP, Jardetzky TS, Woodruff TK
Within the transforming growth factor beta superfamily, the agonist-antagonist relationship between activin and inhibin is unique and critical to integrated reproductive function. Activin acts in the pituitary to…
Regulation of mouse follicle development by follicle-stimulating hormone in a three-dimensional in vitro culture system is dependent on follicle stage and dose.
Biol Reprod. 2005 Nov;73(5):942-50
Authors: Kreeger PK, Fernandes NN, Woodruff TK, Shea LD
The developmental requirements of ovarian follicles are dependent on the maturation stage of the follicle; in particular, elegant studies with genetic models have…
The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding.
Dev Cell. 2005 Oct;9(4):535-43
Authors: Thompson TB, Lerch TF, Cook RW, Woodruff TK, Jardetzky TS
TGF-beta ligands stimulate diverse cellular differentiation and growth responses by signaling through type I and II receptors. Ligand antagonists, such as follistatin, block signaling and are…
A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling.
J Am Chem Soc. 2005 Sep 28;127(38):13164-6
Authors: Lee J, Zylka MJ, Anderson DJ, Burdette JE, Woodruff TK, Meade TJ
We have synthesized the first steroid hormone-MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has…
Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells.
Cancer Res. 2005 Sep 1;65(17):7968-75
Authors: Burdette JE, Jeruss JS, Kurley SJ, Lee EJ, Woodruff TK
The transforming growth factor-beta (TGF-beta) superfamily of growth factors is responsible for a variety of physiologic actions, including cell cycle regulation. Activin is a member of…