The mouse follicle microenvironment regulates antrum formation and steroid production: alterations in gene expression profiles.
Biol Reprod. 2009 Mar;80(3):432-9
Authors: West-Farrell ER, Xu M, Gomberg MA, Chow YH, Woodruff TK, Shea LD
Abstract Folliculogenesis is a coordinated process, and the genes that regulate development are difficult to investigate in vivo.…
Preservation of fertility in patients with cancer.
N Engl J Med. 2009 Feb 26;360(9):902-11
Authors: Jeruss JS, Woodruff TK
PMID: 19246362 [PubMed - indexed for MEDLINE]
Suppression of Notch signaling in the neonatal mouse ovary decreases primordial follicle formation.
Endocrinology. 2009 Feb;150(2):1014-24
Authors: Trombly DJ, Woodruff TK, Mayo KE
Abstract Notch signaling directs cell fate during embryogenesis by influencing cell proliferation, differentiation, and apoptosis. Notch genes are expressed in the adult mouse ovary, and roles for…
Roles for transforming growth factor beta superfamily proteins in early folliculogenesis.
Semin Reprod Med. 2009 Jan;27(1):14-23
Authors: Trombly DJ, Woodruff TK, Mayo KE
Abstract Primordial follicle formation and the subsequent transition of follicles to the primary and secondary stages encompass the early events during folliculogenesis in mammals. These processes establish…
An activin/furin regulatory loop modulates the processing and secretion of inhibin alpha- and betaB-subunit dimers in pituitary gonadotrope cells.
J Biol Chem. 2008 Nov 28;283(48):33059-68
Authors: Antenos M, Zhu J, Jetly NM, Woodruff TK
Abstract Of all ligands of the transforming growth factor beta superfamily, inhibins and activins are a…
Making eggs: is it now or later?
Nat Med. 2008 Nov;14(11):1190-1
Authors: Woodruff TK
PMID: 18989303 [PubMed - indexed for MEDLINE]
Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing.
Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing.
Fertil Steril. 2008 Oct;90(4):911-40
Authors: Crain DA, Janssen SJ, Edwards TM, Heindel J, Ho SM, Hunt P, Iguchi T, Juul A, McLachlan JA, Schwartz J, Skakkebaek N, Soto AM, Swan S, Walker C, Woodruff TK, Woodruff TJ, Giudice LC, Guillette LJ
Abstract …
The role of activin A and Akt/GSK signaling in ovarian tumor biology.
Endocrinology. 2008 Aug;149(8):3809-16
Authors: Do TV, Kubba LA, Antenos M, Rademaker AW, Sturgis CD, Woodruff TK
Abstract Elevated activin A levels in serum, cyst fluid, and peritoneal fluid of ovarian cancer patients suggest a role for this peptide…
An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo.
Endocrinology. 2008 Jun;149(6):2970-9
Authors: Sinkevicius KW, Burdette JE, Woloszyn K, Hewitt SC, Hamilton K, Sugg SL, Temple KA, Wondisford FE, Korach KS, Woodruff TK, Greene GL
Abstract Estrogen-nonresponsive estrogen receptor-alpha (ERalpha) knock-in…
Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition.
Mol Cancer Res. 2008 May;6(5):695-705
Authors: Do TV, Kubba LA, Du H, Sturgis CD, Woodruff TK
Abstract Transforming growth factor-beta (TGF-beta) is thought to play a role in the…
Fetal and early postnatal environmental exposures and reproductive health effects in the female.
Fertil Steril. 2008 Feb;89(2 Suppl):e47-51
Authors: Woodruff TK, Walker CL
Abstract This short review presents current research into the role of the environment in normal female reproductive function and pathogenesis, specifically focusing on the ovary and uterus.…
Smad3 and Pitx2 cooperate in stimulation of FSHbeta gene transcription.
Mol Cell Endocrinol. 2008 Jan 16;281(1-2):27-36
Authors: Suszko MI, Antenos M, Balkin DM, Woodruff TK
Abstract Activin is a member of the TGFbeta superfamily of growth and differentiation factors that control a variety of cellular and physiological functions. The canonical…
Activin regulates estrogen receptor gene expression in the mouse ovary.
J Biol Chem. 2007 Dec 14;282(50):36755-65
Authors: Kipp JL, Kilen SM, Woodruff TK, Mayo KE
Abstract Activin, a member of the transforming growth factor-beta superfamily, is an important modulator of follicle-stimulating hormone synthesis and secretion in the pituitary and plays…
The role of the extracellular matrix in ovarian follicle development.
Reprod Sci. 2007 Dec;14(8 Suppl):6-10
Authors: Woodruff TK, Shea LD
Abstract Regulation of ovarian follicle development depends on endocrine- and paracrine-acting hormones, the 3-dimensional architecture of the follicle, and the physical rigidity of the surrounding tissue. These 3 forces are…
Physical properties of alginate hydrogels and their effects on in vitro follicle development.
Biomaterials. 2007 Oct;28(30):4439-48
Authors: West ER, Xu M, Woodruff TK, Shea LD
Abstract The mechanical properties and density of natural and synthetic extracellular matrices are known to affect cellular processes and regulate tissue formation. In this report,…
Activin and estrogen crosstalk regulates transcription in human breast cancer cells.
Endocr Relat Cancer. 2007 Sep;14(3):679-89
Authors: Burdette JE, Woodruff TK
Abstract Activin is a member of the transforming growth factor beta superfamily that regulates mammary cell function during development, lactation, and in cancer. Activin slows the growth of breast…
Eggs in the nest.
Endocrinology. 2007 Aug;148(8):3577-9
Authors: Mayo K, Jameson L, Woodruff TK
PMID: 17639032 [PubMed - indexed for MEDLINE]
Ovarian epithelial inclusion cysts in chronically superovulated CD1 and Smad2 dominant-negative mice.
Endocrinology. 2007 Aug;148(8):3595-604
Authors: Burdette JE, Oliver RM, Ulyanov V, Kilen SM, Mayo KE, Woodruff TK
Abstract Chronic ovulation as a contributing factor for the development of epithelial ovarian cancer in women has long been an outstanding hypothesis.…
N-linked oligosaccharides direct the differential assembly and secretion of inhibin alpha- and betaA-subunit dimers.
Mol Endocrinol. 2007 Jul;21(7):1670-84
Authors: Antenos M, Stemler M, Boime I, Woodruff TK
Abstract The biosynthetic pathway governing inhibin heterodimer (alpha/beta) and activin homodimer (beta/beta) assembly and secretion from ovarian granulosa cells is not fully understood.…
Engineering the follicle microenvironment.
Semin Reprod Med. 2007 Jul;25(4):287-99
Authors: West ER, Shea LD, Woodruff TK
Abstract In vitro ovarian follicle culture provides a tool to investigate folliculogenesis, and may one day provide women with fertility-preservation options. The application of tissue engineering principles to ovarian follicle maturation may enable the…
Rational design, synthesis, and biological evaluation of progesterone-modified MRI contrast agents.
Chem Biol. 2007 Jul;14(7):824-34
Authors: Lee J, Burdette JE, MacRenaris KW, Mustafi D, Woodruff TK, Meade TJ
Abstract A series of contrast agents for magnetic resonance imaging (MRI) aimed at noninvasively determining the hormone receptor status of cancer in…
Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions.
Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions.
J Biol Chem. 2007 May 25;282(21):15930-9
Authors: Lerch TF, Shimasaki S, Woodruff TK, Jardetzky TS
Abstract Follistatin (FS) regulates transforming growth factor-beta superfamily ligands and is necessary for normal embryonic and ovarian follicle development. Follistatin is expressed…
Neonatal exposure to estrogens suppresses activin expression and signaling in the mouse ovary.
Endocrinology. 2007 May;148(5):1968-76
Authors: Kipp JL, Kilen SM, Bristol-Gould S, Woodruff TK, Mayo KE
Abstract In the ovary, the steroid hormone estrogen and the TGF-beta superfamily member activin are both produced by granulosa cells and they both…
The structures that underlie normal reproductive function.
Mol Cell Endocrinol. 2007 Mar 15;267(1-2):1-5
Authors: Lerch TF, Xu M, Jardetzky TS, Mayo KE, Radhakrishnan I, Kazer R, Shea LD, Woodruff TK
Abstract The mechanisms and physiology of reproductive function have fascinated scientists throughout time. Recent cellular and molecular level structural studies…