Role of androgens in testicular tumor development in inhibin-deficient mice.
Endocrinology. 1997 Nov;138(11):5000-5
Authors: Shou W, Woodruff TK, Matzuk MM
To understand gonadal tumor development, we have previously created a mouse model in which mice deficient in the inhibins develop gonadal sex cord-stromal tumors with essentially 100% penetrance. These tumors develop as early as 4 weeks of age…
High levels of fetal membrane activin beta A and activin receptor IIB mRNAs and augmented concentration of amniotic fluid activin A in women in term or preterm labor.
J Endocrinol. 1997 Jul;154(1):95-101
Authors: Petraglia F, Di Blasio AM, Florio P, Gallo R, Genazzani AR, Woodruff TK, Vale W
The aim of the present study was to evaluate whether…
The uterine myometrium is a target for increased levels of activin A during pregnancy
Endocrinology. 1997 Jul;138(7):3042-6
Authors: Draper LB, Chong H, Wang E, Woodruff TK
Abstract:
Activin A is a dimeric protein hormone that regulates numerous cellular functions. A clear physiological role for this molecule in pregnancy is suggested by previous studies in the human, wherein activin A rises…
Labeling inhibin and identifying inhibin binding to cell surface receptors
Methods Enzymol. 1991;198:347-58
Authors: Woodruff TK, Battaglia J, Borree J, Rice GC, Mather JP
doi: 10.1016/0076-6879(91)98036-6. PMID: 1649953.
Activin stimulates spermatogonial proliferation in germ-Sertoli cell cocultures from immature rat testis
Endocrinology. 1990 Dec;127(6):3206-14
Authors: Mather JP, Attie KM, Woodruff TK, Rice GC, Phillips DM
Abstract:
Activin and inhibin are peptide hormones produced in the gonads which may act as autocrine and/or paracrine regulators of testicular function. Sertoli cells produce inhibin, and it has recently been shown that Leydig…
Inhibin and activin locally regulate rat ovarian folliculogenesis
Endocrinology. 1990 Dec;127(6):3196-205
Authors: Woodruff TK, Lyon RJ, Hansen SE, Rice GC, Mather JP
Abstract:
The role of inhibin and activin in the initiation of follicular development, growth, and atresia was examined. Human recombinant inhibin (1 microgram) was unilaterally injected into the ovarian intrabursal space of 25-day-old rats. The contralateral ovary served…
Regulation of inhibin synthesis in the rat ovary
Annu Rev Physiol. 1990;52:807-21
Authors: Woodruff TK, Mayo KE
Abstract:
The lifespan of the female rodent is characterized by dynamic changes in the hormonal regulation of the reproductive axis. From the time ovarian follicular growth is initiated in peripubertal animals, through recruitment, ovulation and luteinization during the estrous cycle, to the quiescent…
Decreased inhibin gene expression in preovulatory follicles requires primary gonadotropin surges
Endocrinology. 1989 May;124(5):2193-9
Authors: Woodruff TK, D'Agostino J, Schwartz NB, Mayo KE
Abstract:
We have examined the role of the primary gonadotropin surges in regulating inhibin alpha- and beta A-subunit mRNA levels in rat ovarian follicles. Inhibin subunit mRNA levels decline dramatically on the evening of proestrus in follicles…
Unilateral ovariectomy increases inhibin messenger ribonucleic acid levels in newly recruited follicles
Endocrinology. 1989 Jan;124(1):310-7
Authors: D'Agostino J, Woodruff TK, Mayo KE, Schwartz NB
Abstract:
We have used the unilaterally ovariectomized (ULO) rat as an experimental model to assess transient relationships between follicular recruitment and inhibin mRNA levels in the ovary. Animals were divided into three experimental groups (ULO, sham-operated,…
Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle
Science. 1988 Mar 11;239(4845):1296-9
Authors: Woodruff TK, D'Agostino J, Schwartz NB, Mayo KE
Abstract:
The alterations in morphology and function of the ovarian follicle as it matures, ovulates, and becomes a corpus luteum are dramatic. A variety of steroid and polypeptide hormones influence these processes, and…
Rat inhibin: molecular cloning of alpha- and beta-subunit complementary deoxyribonucleic acids and expression in the ovary
Mol Endocrinol. 1987 Aug;1(8):561-8
Authors: Woodruff TK, Meunier H, Jones PB, Hsueh AJ, Mayo KE
Abstract:
Inhibin is a gonadal protein hormone that suppresses the secretion of FSH from pituitary gonadotrophs. It has previously been characterized as a heterodimer of two dissimilar subunits (alpha,…
mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence
Mol Cell Biol. 1986 Aug;6(8):2932-43
Authors: Adam SA, Nakagawa T, Swanson MS, Woodruff TK, Dreyfuss G
Abstract:
We identified and produced antibodies to the major proteins that interact with poly(A)+ RNAs in the yeast Saccharomyces cerevisiae. The major proteins which were cross-linked by UV light to…