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Sex-based biomedical research policy needs an implementation plan.

Sex-based biomedical research policy needs an implementation plan. Womens Health (Lond Engl). 2015 Aug 3;:1-4 Authors: Woodruff TK, Green S, Paller A, Schlosser BJ, Spring B, Castle M, Stock MC, Carnethon MR, Clark CT, Gerard E, Turek FW, Wisner KL, Wakschlag LS, Kibbe MR, Mendelson MA, Simon MA, Hansen NM, Kenton K, Garcia PM, Zee P, Ramsey-Goldman…

Virtual High Throughput Screening to identify novel activin antagonists.

Virtual High Throughput Screening to identify novel activin antagonists. J Med Chem. 2015 Jun 22; Authors: Zhu J, Mishra RK, Schiltz G, Makanji Y, Scheidt KA, Mazar A, Woodruff TK Abstract Activin belongs to the TGFβ superfamily, which is associated with several disease conditions including cancer-related cachexia, preterm labor with delivery,…

Initiation of puberty in mice following decellularized ovary transplant.

Initiation of puberty in mice following decellularized ovary transplant. Biomaterials. 2015 May;50:20-9 Authors: Laronda MM, Jakus AE, Whelan KA, Wertheim JA, Shah RN, Woodruff TK Abstract Clinical interventions to preserve fertility and restore hormone levels in female patients with therapy-induced ovarian failure are insufficient, particularly for pediatric cancer patients. Laparoscopic isolation…

Opinion: Sex inclusion in basic research drives discovery.

Opinion: Sex inclusion in basic research drives discovery. Proc Natl Acad Sci U S A. 2015 Apr 20; Authors: Klein SL, Schiebinger L, Stefanick ML, Cahill L, Danska J, de Vries GJ, Kibbe MR, McCarthy MM, Mogil JS, Woodruff TK, Zucker I PMID: 25902532 [PubMed - as supplied by publisher]

Engineering the ovarian cycle using in vitro follicle culture.

Engineering the ovarian cycle using in vitro follicle culture. Hum Reprod. 2015 Mar 16; Authors: Skory RM, Xu Y, Shea LD, Woodruff TK Abstract STUDY QUESTION: Can cultured follicles model the ovarian cycle, including follicular- and luteal-phase hormone synthesis patterns and ovulation? SUMMARY ANSWER:…

Use of an organotypic mammalian in vitro follicle growth assay to facilitate female reproductive toxicity screening.

Use of an organotypic mammalian in vitro follicle growth assay to facilitate female reproductive toxicity screening. Reprod Fertil Dev. 2015 Feb 18; Authors: Xu Y, Duncan FE, Xu M, Woodruff TK Abstract Screening of pharmaceutical, chemical and environmental compounds for their effects on reproductive health relies on in vivo studies. More…

Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles.

Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles. Endocrinology. 2015 Jan 16;:en20141926 Authors: Kim SY, Ebbert K, Cordeiro MH, Romero M, Zhu J, Ann Serna V, Whelan KA, Woodruff TK, Kurita T Abstract In this study, we explored the effects…

Three-dimensional modeling of the human fallopian tube fimbriae.

Three-dimensional modeling of the human fallopian tube fimbriae. Gynecol Oncol. 2014 Dec 16; Authors: Eddie SL, Quartuccio SM, Zhu J, Shepherd JA, Kothari R, Julie Kim J, Woodruff TK, Burdette JE Abstract OBJECTIVE: Ovarian cancer is the most lethal gynecological malignancy that affects women. Recent data suggests the disease may originate…

Multi-modal magnetic resonance elastography for noninvasive assessment of ovarian tissue rigidity in vivo.

Multi-modal magnetic resonance elastography for noninvasive assessment of ovarian tissue rigidity in vivo. Acta Biomater. 2014 Nov 20; Authors: Wood CD, Vijayvergia M, Miller FH, Carroll T, Fasanati C, Shea LD, Catherine Brinson L, Woodruff TK Abstract For centuries, physicians have relied on touch to palpate tissue and detect abnormalities throughout…

Fertility preservation in women with cancer.

Fertility preservation in women with cancer. Lancet. 2014 Oct 4;384(9950):1302-10 Authors: De Vos M, Smitz J, Woodruff TK Abstract Enhanced long-term survival rates of young women with cancer and advances in reproductive medicine and cryobiology have culminated in an increased interest in fertility preservation methods in girls and young women with…

Sex bias exists in basic science and translational surgical research.

Sex bias exists in basic science and translational surgical research. Surgery. 2014 Sep;156(3):508-16 Authors: Yoon DY, Mansukhani NA, Stubbs VC, Helenowski IB, Woodruff TK, Kibbe MR Abstract BACKGROUND: Although the Revitalization Act was passed in 1993 to increase enrollment of women in clinical trials, there has been little focus on sex…

Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition.

Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition. Mol Hum Reprod. 2014 Aug 20; Authors: Kong BY, Duncan FE, Que EL, Kim AM, OÕHalloran TV, Woodruff TK Abstract Rapid cellular zinc influx regulates early mammalian development during the oocyte-to-egg transition through modulation of the meiotic cell cycle. Despite…

Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue.

Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue. J Assist Reprod Genet. 2014 May 21; Authors: Laronda MM, Duncan FE, Hornick JE, Xu M, Pahnke JE, Whelan KA, Shea LD, Woodruff TK Abstract PURPOSE: In vitro follicle growth (IVFG) is an investigational fertility preservation…