Sex-based biomedical research policy needs an implementation plan.
Womens Health (Lond Engl). 2015 Aug 3;:1-4
Authors: Woodruff TK, Green S, Paller A, Schlosser BJ, Spring B, Castle M, Stock MC, Carnethon MR, Clark CT, Gerard E, Turek FW, Wisner KL, Wakschlag LS, Kibbe MR, Mendelson MA, Simon MA, Hansen NM, Kenton K, Garcia PM, Zee P, Ramsey-Goldman…
Oncofertility: A Grand Collaboration Between Reproductive Medicine and Oncology.
Reproduction. 2015 Jun 30;
Authors: Woodruff TK
Abstract
In 2007, I was asked by the University of Calgary to participate in a symposium called "Pushing the Boundaries - Advances That Will Change the World in 20 Years." My topic was oncofertility, a…
Size-specific follicle selection improves mouse oocyte reproductive outcomes.
Reproduction. 2015 Jun 26;
Authors: Xiao S, Duncan FE, Bai L, Nguyen CT, Shea LD, Woodruff TK
Abstract
Encapsulated in vitro follicle growth (eIVFG) has great potential to provide an additional fertility preservation option for young women and girls with cancer or other…
Virtual High Throughput Screening to identify novel activin antagonists.
J Med Chem. 2015 Jun 22;
Authors: Zhu J, Mishra RK, Schiltz G, Makanji Y, Scheidt KA, Mazar A, Woodruff TK
Abstract
Activin belongs to the TGFβ superfamily, which is associated with several disease conditions including cancer-related cachexia, preterm labor with delivery,…
Initiation of puberty in mice following decellularized ovary transplant.
Biomaterials. 2015 May;50:20-9
Authors: Laronda MM, Jakus AE, Whelan KA, Wertheim JA, Shah RN, Woodruff TK
Abstract
Clinical interventions to preserve fertility and restore hormone levels in female patients with therapy-induced ovarian failure are insufficient, particularly for pediatric cancer patients. Laparoscopic isolation…
The inorganic anatomy of the mammalian preimplantation embryo and the requirement of zinc during the first mitotic divisions.
Dev Dyn. 2015 Apr 22;
Authors: Kong BY, Duncan FE, Que EL, Xu Y, Vogt S, O'Halloran TV, Woodruff TK
Abstract
BACKGROUND: Zinc is the most abundant transition metal in the mammalian oocyte,…
Opinion: Sex inclusion in basic research drives discovery.
Proc Natl Acad Sci U S A. 2015 Apr 20;
Authors: Klein SL, Schiebinger L, Stefanick ML, Cahill L, Danska J, de Vries GJ, Kibbe MR, McCarthy MM, Mogil JS, Woodruff TK, Zucker I
PMID: 25902532 [PubMed - as supplied by publisher]
Engineering the ovarian cycle using in vitro follicle culture.
Hum Reprod. 2015 Mar 16;
Authors: Skory RM, Xu Y, Shea LD, Woodruff TK
Abstract
STUDY QUESTION: Can cultured follicles model the ovarian cycle, including follicular- and luteal-phase hormone synthesis patterns and ovulation?
SUMMARY ANSWER:…
Age-associated alterations in the micromechanical properties of chromosomes in the mammalian egg.
J Assist Reprod Genet. 2015 Mar 11;
Authors: Hornick JE, Duncan FE, Sun M, Kawamura R, Marko JF, Woodruff TK
Abstract
PURPOSE: The incidence of aneuploidy in eggs from women of advanced reproductive age can exceed 60 %, making the…
Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks.
Nat Chem. 2015 Feb;7(2):130-139
Authors: Que EL, Bleher R, Duncan FE, Kong BY, Gleber SC, Vogt S, Chen S, Garwin SA, Bayer AR, Dravid VP, Woodruff TK, O'Halloran TV
Abstract
Fertilization of a mammalian egg…
Use of an organotypic mammalian in vitro follicle growth assay to facilitate female reproductive toxicity screening.
Reprod Fertil Dev. 2015 Feb 18;
Authors: Xu Y, Duncan FE, Xu M, Woodruff TK
Abstract
Screening of pharmaceutical, chemical and environmental compounds for their effects on reproductive health relies on in vivo studies. More…
Novel Three Dimensional Human Endocervix Cultures respond to 28-day hormone treatment.
Endocrinology. 2015 Jan 30;:en20141840
Authors: Arslan SY, Yu Y, Burdette JE, Pavone ME, Hope TJ, Woodruff TK, Kim JJ
Abstract
The endocervix has both anatomical and biological functions that participate in the delicate balance between tolerance necessary for conception and…
Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles.
Endocrinology. 2015 Jan 16;:en20141926
Authors: Kim SY, Ebbert K, Cordeiro MH, Romero M, Zhu J, Ann Serna V, Whelan KA, Woodruff TK, Kurita T
Abstract
In this study, we explored the effects…
Three-dimensional modeling of the human fallopian tube fimbriae.
Gynecol Oncol. 2014 Dec 16;
Authors: Eddie SL, Quartuccio SM, Zhu J, Shepherd JA, Kothari R, Julie Kim J, Woodruff TK, Burdette JE
Abstract
OBJECTIVE: Ovarian cancer is the most lethal gynecological malignancy that affects women. Recent data suggests the disease may originate…
Multi-modal magnetic resonance elastography for noninvasive assessment of ovarian tissue rigidity in vivo.
Acta Biomater. 2014 Nov 20;
Authors: Wood CD, Vijayvergia M, Miller FH, Carroll T, Fasanati C, Shea LD, Catherine Brinson L, Woodruff TK
Abstract
For centuries, physicians have relied on touch to palpate tissue and detect abnormalities throughout…
Fertility preservation in women with cancer.
Lancet. 2014 Oct 4;384(9950):1302-10
Authors: De Vos M, Smitz J, Woodruff TK
Abstract
Enhanced long-term survival rates of young women with cancer and advances in reproductive medicine and cryobiology have culminated in an increased interest in fertility preservation methods in girls and young women with…
Sex bias exists in basic science and translational surgical research.
Surgery. 2014 Sep;156(3):508-16
Authors: Yoon DY, Mansukhani NA, Stubbs VC, Helenowski IB, Woodruff TK, Kibbe MR
Abstract
BACKGROUND: Although the Revitalization Act was passed in 1993 to increase enrollment of women in clinical trials, there has been little focus on sex…
Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition.
Mol Hum Reprod. 2014 Aug 20;
Authors: Kong BY, Duncan FE, Que EL, Kim AM, OÕHalloran TV, Woodruff TK
Abstract
Rapid cellular zinc influx regulates early mammalian development during the oocyte-to-egg transition through modulation of the meiotic cell cycle. Despite…
Inhibin at 90: From Discovery to Clinical Application, A Historical Review.
Endocr Rev. 2014 Jul 22;:er20141003
Authors: Makanji Y, Zhu J, Mishra R, Holmquist C, Wong WP, Schwartz NB, Mayo KE, Woodruff TK
Abstract
When it was initially discovered in 1923, inhibin was characterized as a hypophysiotropic hormone that acts on…
Fertility Preservation Preferences and Perspectives Among Adult Male Survivors of Pediatric Cancer and Their Parents.
J Adolesc Young Adult Oncol. 2014 Jun 1;3(2):75-82
Authors: Stein DM, Victorson DE, Choy JT, Waimey KE, Pearman TP, Smith K, Dreyfuss J, Kinahan KE, Sadhwani D, Woodruff TK, Brannigan RE
Abstract
Purpose: In this study,…
Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue.
J Assist Reprod Genet. 2014 May 21;
Authors: Laronda MM, Duncan FE, Hornick JE, Xu M, Pahnke JE, Whelan KA, Shea LD, Woodruff TK
Abstract
PURPOSE: In vitro follicle growth (IVFG) is an investigational fertility preservation…
Microphysiological modeling of the reproductive tract: A fertile endeavor.
Exp Biol Med (Maywood). 2014 Apr 15;
Authors: Eddie SL, Kim JJ, Woodruff TK, Burdette JE
Abstract
Preclinical toxicity testing in animal models is a cornerstone of the drug development process, yet it is often unable to predict adverse effects and tolerability…
Sex, equity, and science.
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5063-4
Authors: Woodruff TK
PMID: 24715722 [PubMed - in process]
Keeping reproductive science visible, viable, and valuable-a call to rethink how we publish.
J Assist Reprod Genet. 2014 Mar 28;
Authors: Duncan FE, Woodruff TK
PMID: 24677209 [PubMed - as supplied by publisher]